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المؤلفAlzaim, Ibrahim
المؤلفAl-Saidi, Aya
المؤلفHammoud, Safaa H.
المؤلفDarwiche, Nadine
المؤلفAl-Dhaheri, Yusra
المؤلفEid, Ali H.
المؤلفEl-Yazbi, Ahmed F.
تاريخ الإتاحة2023-09-04T08:07:30Z
تاريخ النشر2022-04-01
اسم المنشورCancers
المعرّفhttp://dx.doi.org/10.3390/cancers14071679
الاقتباسAlZaim, I., Al-Saidi, A., Hammoud, S. H., Darwiche, N., Al-Dhaheri, Y., Eid, A. H., & El-Yazbi, A. F. (2022). Thromboinflammatory processes at the nexus of metabolic dysfunction and prostate cancer: The emerging role of periprostatic adipose tissue. Cancers, 14(7), 1679.‏
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85127086714&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47226
الملخصThe increased global prevalence of metabolic disorders including obesity, insulin resistance, metabolic syndrome and diabetes is mirrored by an increased incidence of prostate cancer (PCa). Ample evidence suggests that these metabolic disorders, being characterized by adipose tissue (AT) expansion and inflammation, not only present as risk factors for the development of PCa, but also drive its increased aggressiveness, enhanced progression, and metastasis. Despite the emerging molecular mechanisms linking AT dysfunction to the various hallmarks of PCa, thromboinflammatory processes implicated in the crosstalk between these diseases have not been thoroughly investigated. This is of particular importance as both diseases present states of hypercoagulability. Accumulating evidence implicates tissue factor, thrombin, and active factor X as well as other players of the coagulation cascade in the pathophysiological processes driving cancer development and progression. In this regard, it becomes pivotal to elucidate the thromboinflammatory processes occurring in the periprostatic adipose tissue (PPAT), a fundamental microenvironmental niche of the prostate. Here, we highlight key findings linking thromboinflammation and the pleiotropic effects of coagulation factors and their inhibitors in metabolic diseases, PCa, and their crosstalk. We also propose several novel therapeutic targets and therapeutic interventions possibly modulating the interaction between these pathological states.
اللغةen
الناشرMDPI
الموضوعadipokine
metabolic dysfunction
obesity
periprostatic adipose tissue
prostate cancer
العنوانThromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue
النوعArticle
رقم العدد7
رقم المجلد14
dc.accessType Open Access


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