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AuthorAlzaim, Ibrahim
AuthorAl-Saidi, Aya
AuthorHammoud, Safaa H.
AuthorDarwiche, Nadine
AuthorAl-Dhaheri, Yusra
AuthorEid, Ali H.
AuthorEl-Yazbi, Ahmed F.
Available date2023-09-04T08:07:30Z
Publication Date2022-04-01
Publication NameCancers
Identifierhttp://dx.doi.org/10.3390/cancers14071679
CitationAlZaim, I., Al-Saidi, A., Hammoud, S. H., Darwiche, N., Al-Dhaheri, Y., Eid, A. H., & El-Yazbi, A. F. (2022). Thromboinflammatory processes at the nexus of metabolic dysfunction and prostate cancer: The emerging role of periprostatic adipose tissue. Cancers, 14(7), 1679.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85127086714&origin=inward
URIhttp://hdl.handle.net/10576/47226
AbstractThe increased global prevalence of metabolic disorders including obesity, insulin resistance, metabolic syndrome and diabetes is mirrored by an increased incidence of prostate cancer (PCa). Ample evidence suggests that these metabolic disorders, being characterized by adipose tissue (AT) expansion and inflammation, not only present as risk factors for the development of PCa, but also drive its increased aggressiveness, enhanced progression, and metastasis. Despite the emerging molecular mechanisms linking AT dysfunction to the various hallmarks of PCa, thromboinflammatory processes implicated in the crosstalk between these diseases have not been thoroughly investigated. This is of particular importance as both diseases present states of hypercoagulability. Accumulating evidence implicates tissue factor, thrombin, and active factor X as well as other players of the coagulation cascade in the pathophysiological processes driving cancer development and progression. In this regard, it becomes pivotal to elucidate the thromboinflammatory processes occurring in the periprostatic adipose tissue (PPAT), a fundamental microenvironmental niche of the prostate. Here, we highlight key findings linking thromboinflammation and the pleiotropic effects of coagulation factors and their inhibitors in metabolic diseases, PCa, and their crosstalk. We also propose several novel therapeutic targets and therapeutic interventions possibly modulating the interaction between these pathological states.
Languageen
PublisherMDPI
Subjectadipokine
metabolic dysfunction
obesity
periprostatic adipose tissue
prostate cancer
TitleThromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue
TypeArticle
Issue Number7
Volume Number14
dc.accessType Open Access


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