Show simple item record

AuthorMoltrasio, Chiara
AuthorTricarico, Paola Maura
AuthorMoura, Ronald
AuthorBrandao, Lucas André Cavalcanti
AuthorCrovella, Sergio
AuthorMarzano, Angelo Valerio
Available date2023-09-10T05:23:12Z
Publication Date2023
Publication NameDermatology
Identifierhttp://dx.doi.org/10.1159/000531496
CitationChiara Moltrasio, Paola Maura Tricarico, Ronald Rodrigues Moura, Lucas Brandão, Sergio Crovella, Angelo Valerio Marzano; Clinical and Molecular Characterization of Hidradenitis Suppurativa: A Practical Framework for Novel Therapeutic Targets. Dermatology 2023; https://doi.org/10.1159/000531496
ISSN1018-8665
URIhttp://hdl.handle.net/10576/47335
AbstractBackground: The pathophysiological picture underlying hidradenitis suppurativa (HS) and its syndromic forms is still patchy, thus presenting a great challenge for dermatologists and researchers since just by better understanding the pathogenesis of disease we could identify novel therapeutic targets. Methods: We propose a practical framework to improve subcategorization of HS patients and support the genotype-phenotype correlation, useful for endotype-directed therapies development. Results: This framework includes (i) clinical work-up that involves the collection of demographic, lifestyle, and clinical data as well as the collection of different biological samples; (ii) genetic-molecular work-up, based on multi-omics analysis in combination with bioinformatics pipelines to unravel the complex etiology of HS and its syndromic forms; (iii) functional studies, – represented by skin fibroblast cell cultures, reconstructed epidermal models (both 2D and 3D) and organoids –, of candidate biomarkers and genetic findings necessary to validate novel potential molecular mechanisms possibly involved and druggable in HS; (iv) genotype-phenotype correlation and clinical translation in tailored targeted therapies. Conclusion: Omic findings should be merged and integrated with clinical data; moreover, the skin-omic profiles from each HS patient should be matched and integrated with the ones already reported in public repositories, supporting the efforts of the researchers and clinicians to discover novel biomarkers and molecular pathways with the ultimate goal of providing faster development of novel patient-tailored therapeutic approaches.
SponsorThis work was supported by a Biomolecular Analyses for Tailored Medicine in AcneiNversa (BATMAN) project, funded by ERAPerMed, by Starting Grant (SG-2019-12369421) funded by the Italian Ministry of Health, by Grant (RC16/2018) from the Institute for Maternal and Child Health IRCCS “Burlo Garofolo” funded by the Italian Ministry of Health, and by a grant from Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan (protocol No. 487_2020). This work was also partially supported by Italian Ministry of Health (Ricerca Corrente 2023)/Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico of Milan, Italy.
Languageen
PublisherKarger Publishers
SubjectHidradenitis suppurativa
Syndromic forms
Autoinflammatory skin diseases
Causative genetic variants and disrupted pathways
2D-3D cells and organoids models
Biomarkers discovery
Genotype-phenotype correlation
Tailored treatment
TitleClinical and molecular characterization of hidradenitis suppurativa: a practical framework for novel therapeutic targets.
TypeReport
ESSN1421-9832
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record