عرض بسيط للتسجيلة

المؤلفAl-Shammri, Suhail
المؤلفChattopadhyay, Arpita
المؤلفHanah, Magdy Girgis
المؤلفDoi, Suhail
المؤلفAkanji, Abayomi
تاريخ الإتاحة2023-09-13T05:33:12Z
تاريخ النشر2023-06-24
اسم المنشورBiomedicines
المعرّفhttp://dx.doi.org/10.3390/biomedicines11071808
الاقتباسAl-Shammri, S.; Chattopadhyay, A.; Hanah, M.G.; Doi, S.; Akanji, A. Association of Blood Levels of Vitamin D and Its Binding Protein with Clinical Phenotypes of Multiple Sclerosis. Biomedicines 2023, 11, 1808. https://doi.org/10.3390/biomedicines11071808
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47492
الملخصLow vitamin D levels may synergize with changing levels of the vitamin D binding protein (DBP) to precipitate in the development and clinical progression of multiple sclerosis (MS). In this study, this hypothesis was explored in groups of Kuwaiti healthy controls and patients with different clinical phenotypes of MS. Fasting serum concentrations of 25-hydroxyvitamin D [25(OH)D] and DBP were measured in 146 healthy controls and 195 patients with MS. The latter were classified according to the duration, type, and onset of the disease and the mode of treatment. Factors such as relapse/remitting, and the use of nutritional supplements were also considered. The DBP levels were significantly lower in the patients than in the controls. This was more evident in newly diagnosed drug-naïve patients than in those patients with more established MS. MS status and severity were negatively impacted by concurrently low levels of 25(OH)D and DBP. This was most clearly expressed in drug-naïve patients and in those with a disease in relapse. It was also established that the 25(OH)D level had a significant positive correlation with the duration of the disease. Lower levels of 25(OH)D and DBP appear to have a synergistic effect on MS status. This was most clearly demonstrated in patients who were newly diagnosed (drug-naïve) and in those patients who were in relapse.
راعي المشروعThis research was funded by Kuwait University Research Administration; grant number MM 03/09 and the APC was funded by Suhail Al-Shammri.
اللغةen
الناشرMDPI
الموضوع25-hydroxyvitamin D
Kuwait
drug-naïve patients
hypovitaminosis D
multiple sclerosis
relapsing remitting
vitamin D
vitamin D binding protein
العنوانAssociation of Blood Levels of Vitamin D and Its Binding Protein with Clinical Phenotypes of Multiple Sclerosis.
النوعArticle
رقم العدد7
رقم المجلد11
ESSN2227-9059
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة