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AuthorMassadeh, R.K.
AuthorEl-Elimat, T.
AuthorAl-Gharaibeh, M.
AuthorTawaha, K.
AuthorAlali, F.Q.
Available date2023-09-18T09:52:24Z
Publication Date2022
Publication NameActa Pharmaceutica
ResourceScopus
URIhttp://dx.doi.org/10.2478/acph-2022-0001
URIhttp://hdl.handle.net/10576/47637
AbstractThe alkaloid-rich fraction obtained by fractionation of the crude methanolic extract of the leaves of wild tobacco tree Nicotiana glauca Graham (Solanaceae) was analyzed using UPLC-MS and GC-MS. Anabasine, a piperidine alkaloid, was identified as the major constituent with approximately 60 % (m/m) of the alkaloid-rich fraction. In addition to anabasine, six secondary metabolites were identified using high-resolution UPLC-MS. Anabasine was quantified in the leaves to be 1 mg g-1 dry plant material. The GC-MS analysis revealed five compounds with anabasine as the major component, while nicotine was not detected. Moreover, GC-MS was used for the analysis of the volatile oil that was obtained by hydro-distillation from the leaves of N. glauca. The volatile plant oil was found to be rich in oxygenated sesquiterpenes (e.g., ?-bisabolol) and carboxylic acids and esters (e.g., ethyl linoleate and hexadecanoic acid), whereas anabasine was not detected.
Languageen
PublisherHrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society
SubjectTobacco Workers
Cotinine
Nicotiana Tabacum
TitleUPLC-HRESI-MS and GC-MS analysis of the leaves of Nicotiana glauca
TypeArticle
Pagination97-108
Issue Number1
Volume Number72
dc.accessType Open Access


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