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المؤلفMassadeh, R.K.
المؤلفEl-Elimat, T.
المؤلفAl-Gharaibeh, M.
المؤلفTawaha, K.
المؤلفAlali, F.Q.
تاريخ الإتاحة2023-09-18T09:52:24Z
تاريخ النشر2022
اسم المنشورActa Pharmaceutica
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.2478/acph-2022-0001
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47637
الملخصThe alkaloid-rich fraction obtained by fractionation of the crude methanolic extract of the leaves of wild tobacco tree Nicotiana glauca Graham (Solanaceae) was analyzed using UPLC-MS and GC-MS. Anabasine, a piperidine alkaloid, was identified as the major constituent with approximately 60 % (m/m) of the alkaloid-rich fraction. In addition to anabasine, six secondary metabolites were identified using high-resolution UPLC-MS. Anabasine was quantified in the leaves to be 1 mg g-1 dry plant material. The GC-MS analysis revealed five compounds with anabasine as the major component, while nicotine was not detected. Moreover, GC-MS was used for the analysis of the volatile oil that was obtained by hydro-distillation from the leaves of N. glauca. The volatile plant oil was found to be rich in oxygenated sesquiterpenes (e.g., ?-bisabolol) and carboxylic acids and esters (e.g., ethyl linoleate and hexadecanoic acid), whereas anabasine was not detected.
اللغةen
الناشرHrvatsko Farmaceutsko Drustvo/Croatian Pharmaceutical Society
الموضوعTobacco Workers
Cotinine
Nicotiana Tabacum
العنوانUPLC-HRESI-MS and GC-MS analysis of the leaves of Nicotiana glauca
النوعArticle
الصفحات97-108
رقم العدد1
رقم المجلد72
dc.accessType Open Access


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