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المؤلفAlser, M.
المؤلفRamanjaneya, M.
المؤلفAnwardeen, N.R.
المؤلفDonati, F.
المؤلفBotre, F.
المؤلفJerobin, J.
المؤلفBettahi, I.
المؤلفMohamed, N.A.
المؤلفAbou-Samra, A.B.
المؤلفElrayess, M.A.
تاريخ الإتاحة2023-09-18T09:52:25Z
تاريخ النشر2022
اسم المنشورReviews in Cardiovascular Medicine
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.31083/j.rcm2305181
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47647
الملخصBackground: Humanin and the mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) are mitochondrial encoded peptides involved in energy metabolism, cytoprotection, longevity, insulin sensitivity and their expression decrease with age. Levels of these molecules have been shown to respond to acute exercise, however little is known about their modulation under different chronic exercise conditions. In this study, we aim to compare levels of Humanin and MOTS-c in non-athletes vs professional (moderate and high endurance) athletes. Methods: Serum samples were collected from 30 non-athlete controls and 75 professional athletes (47 low/moderate endurance and 28 high endurance athletes). Levels of Humanin and MOTS-c were measured by the enzyme linked immunosorbent aaasy (ELISA) and linear models were generated to compare the effect of different levels of endurance exercise on these factors in different age groups. Spearman correlation was used to assess the correlation between these factors in athletes and non-athletes. Results: We showed that professional athletes had lower levels of MOTS-c and higher levels of Humanin than sedentary controls. Within the athletic groups, high endurance athletes had lower levels of Humanin than low/moderate endurance athletes of the same gender/age groups, whereas MOTS-c levels did not change between the subgroups. Humanin and MOTS-c levels were highly correlated in athletes, but not in sedentary controls. Conclusions: This pilot data suggests that serum levels of the mitochondrial proteins MOTS-c and Humanin change in response to chronic exercise with implications on energy metabolism and performance.
راعي المشروعThis research was funded by the Qatar National Research Fund (QNRF), grant number NPRP13S-1230-190008, and Qatar University, grant number QUCG-BRC-21/22-1 (MAE).
اللغةen
الناشرIMR Press Limited
الموضوعMitochondria
Gly(14)-Humanin
Colivelin
العنوانThe Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes
النوعArticle
رقم العدد5
رقم المجلد23
dc.accessType Open Access


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