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AuthorEl Dahan, Karim Seif
AuthorMachtoub, Dima
AuthorMassoud, Gaelle
AuthorNasser, Suzanne A.
AuthorHamam, Bassam
AuthorKobeissy, Firas
AuthorZouein, Fouad A.
AuthorEid, Ali H.
Available date2023-09-21T08:41:32Z
Publication Date2022-04-01
Publication NameCurrent Medicinal Chemistry
Identifierhttp://dx.doi.org/10.2174/0929867328666210608144818
CitationSeif El Dahan, K., Machtoub, D., Massoud, G., Nasser, S. A., Hamam, B., Kobeissy, F., ... & Eid, A. H. (2022). Cannabinoids and myocardial ischemia: Novel insights, updated mechanisms, and implications for myocardial infarction. Current Medicinal Chemistry, 29(11), 1990-2010.‏
ISSN09298673
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85130157020&origin=inward
URIhttp://hdl.handle.net/10576/47817
AbstractCannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects as compared to other illicit drugs; however, growing evidence clearly indicates that cannabis is associated with considerable adverse cardiovascular events. Recent studies have linked cannabis use to myocardial infarction (MI); yet, very little is known about the underlying mechanisms. A MI is a cardiovascular disease characterized by a mismatch in the oxygen supply and demand of the heart, resulting in ischemia and subsequent necrosis of the myocardium. Since cannabis is increasingly being considered a risk factor for MI, there is a growing need for better appreciating its potential health benefits and consequences. Here, we discuss the cellular mechanisms of cannabis that lead to an increased risk of MI. We provide a thorough and critical analysis of cannabinoids’ actions, which include modulation of adipocyte biology, regional fat distribution, and atherosclerosis, as well as precipitation of hemodynamic stressors relevant in the setting of a MI. By critically dissecting the modulation of signaling pathways in multiple cell types, this paper highlights the mechanisms through which cannabis may trigger life-threatening cardiovascular events. This then provides a framework for future pharmacological studies which can identify targets or develop drugs that modulate cannabis’ effects on the cardiovascular system as well as other organ systems. Cannabis’ impact on the autonomic outflow, vascular smooth muscle cells, myocardium, cortisol levels and other hemodynamic changes are also mechanistically reviewed.
Languageen
PublisherBentham Science Publishers
SubjectAtherosclerosis
Cannabis
Cardiovascular disease
Endocannabinoid system
Myocardial infarction
Tetrahydrocannabinol
TitleCannabinoids and Myocardial Ischemia: Novel insights, Updated Mechanisms, and Implications for Myocardial Infarction
TypeArticle
Pagination1990-2010
Issue Number11
Volume Number29
dc.accessType Abstract Only


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