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AuthorAnwar, Mohammad A.
AuthorEid, Ali H.
Available date2023-09-25T10:26:15Z
Publication Date2016
Publication NameMethods in Molecular Biology
ResourceScopus
URIhttp://dx.doi.org/10.1007/978-1-4939-3816-2_33
URIhttp://hdl.handle.net/10576/47932
AbstractStroke and other neurovascular derangements are main causes of global death. They, along with spinal cord injuries, are responsible for being the principal cause of disability due to neurological and cognitive problems. These problems then lead to a burden on scarce financial resources and societal care facilities as well as have a profound effect on patients' families. The mechanism of action in these debilitating diseases is complex and unclear. An important component of these problems arises from derangement of blood vessels, such as blockage due to clotting/embolism, endothelial dysfunction, and overreactivity to contractile agents, as well as alteration in endothelial permeability. Moreover, the cerebro-vasculature (large vessels and arterioles) is involved in regulating blood flow by facilitating auto-regulatory processes. Moreover, the anterior (middle cerebral artery and the surrounding region) and posterior (basilar artery and its immediate locality) regions of the brain play a significant role in triggering the pathological progression of ischemic stroke particularly due to inflammatory activity and oxidative stress. Interestingly, modifiable and non-modifiable cardiovascular risk factors are responsible for driving ischemic and hemorrhagic stroke and spinal cord injury. There are different stroke animal models to examine the pathophysiology of middle cerebral and basilar arteries. In this context, arterial myography offers an opportunity to determine the etiology of vascular dysfunction in these diseases. Herein, we describe the technique of pressure myography to examine the reactivity of cerebral vessels to contractile and vasodilator agents and a prelude to stroke and spinal cord injury.
Languageen
PublisherHumana Press Inc.
SubjectBasilar artery
Brain injury
Middle cerebral artery
Middle cerebral artery
Peripheral arterial disease
Pressure myography
Spinal cord injury
Spinal cord injury
Stroke
TitleDetermination of vascular reactivity of middle cerebral arteries from stroke and spinal cord injury animal models using pressure myography
TypeBook chapter
Pagination611-624
Volume Number1462
dc.accessType Abstract Only


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