Show simple item record

AuthorBhagani, Humna
AuthorNasser, Suzanne A.
AuthorDakroub, Ali
AuthorEl-Yazbi, Ahmed F.
AuthorEid, Assaad A.
AuthorKobeissy, Firas
AuthorPintus, Gianfranco
AuthorEid, Ali H.
Available date2023-09-25T10:26:16Z
Publication Date2020
Publication NameInternational Journal of Molecular Sciences
ResourceScopus
URIhttp://dx.doi.org/10.3390/ijms21144962
URIhttp://hdl.handle.net/10576/47945
AbstractDiabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; however, several processes involving the mitochondria, such as lipid and glucose metabolism, reactive oxygen species (ROS) production, apoptosis, autophagy and mitochondrial biogenesis have been implicated. In addition, polyphenols have been shown to improve the progression of diabetes. In this review, we discuss some of the mechanisms by which polyphenols, particularly resveratrol, play a role in slowing the progression of DCM. The most important intermediates by which polyphenols exert their protective effect include Bcl-2, UCP2, SIRT-1, AMPK and JNK1. Bcl-2 acts to attenuate apoptosis, UCP2 decreases oxidative stress, SIRT-1 increases mitochondrial biogenesis and decreases oxidative stress, AMPK increases autophagy, and JNK1 decreases apoptosis and increases autophagy. Our dissection of these molecular players aims to provide potential therapeutic targets for the treatment of DCM.
SponsorFunding: This work has been made possible by (UNISS fondo di ateneo per la ricerca 2019) grant to G.P., and an MPP 320133 fund from the American University of Beirut (AHE).
Languageen
PublisherMDPI
SubjectAutophagy
Diabetic cardiomyopathy
Polyphenols
Resveratrol
TitleThe mitochondria: A target of polyphenols in the treatment of diabetic cardiomyopathy
TypeArticle
Pagination1-12
Issue Number14
Volume Number21
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record