Show simple item record

AuthorBadran, Adnan
AuthorNasser, Suzanne A.
AuthorMesmar, Joelle
AuthorEl-Yazbi, Ahmed F.
AuthorBitto, Alessandra
AuthorFardoun, Manal M.
AuthorBaydoun, Elias
AuthorEid, Ali H.
Available date2023-09-25T10:26:16Z
Publication Date2020
Publication NameInternational Journal of Molecular Sciences
ResourceScopus
URIhttp://dx.doi.org/10.3390/ijms21228764
URIhttp://hdl.handle.net/10576/47947
AbstractReactive oxygen species (ROS) are natural byproducts of oxygen metabolism in the cell. At physiological levels, they play a vital role in cell signaling. However, high ROS levels cause oxidative stress, which is implicated in cardiovascular diseases (CVD) such as atherosclerosis, hypertension, and restenosis after angioplasty. Despite the great amount of research conducted to identify the role of ROS in CVD, the image is still far from being complete. A common event in CVD pathophysiology is the switch of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic phenotype. Interestingly, oxidative stress is a major contributor to this phenotypic switch. In this review, we focus on the effect of ROS on the hallmarks of VSMC phenotypic switch, particularly proliferation and migration. In addition, we speculate on the underlying molecular mechanisms of these cellular events. Along these lines, the impact of ROS on the expression of contractile markers of VSMCs is discussed in depth. We conclude by commenting on the efficiency of antioxidants as CVD therapies.
SponsorThis work was supported by the American University of Beirut (Grant # MPP 320133 and Farouk Jabre Award to A.E.), University of Petra (Grant #: 5/4/2019) to A.B., E.B., and A.E., and the National Council for Scientific Research (CNRS) to M.M.F.
Languageen
PublisherMDPI
SubjectCardiovascular disease
Phenotypic switch
Reactive oxygen species
Vascular smooth muscle cell
TitleReactive oxygen species: Modulators of phenotypic switch of vascular smooth muscle cells
TypeArticle Review
Pagination1-21
Issue Number22
Volume Number21
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record