Browsing College of Health Sciences by Publisher "American Society for Biochemistry and Molecular Biology"

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A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

Ibrahim, Ahmed S.; Elshafey, Sally; Sellak, Hassan; Hussein, Khaled A.; El-Sherbiny, Mohamed; Abdelsaid, Mohammed; Rizk, Nasser; Beasley, Selina; Tawfik, Amany M.; Smith, Sylvia B.; Al-Shabrawey, Mohamed... more authors ... less authors ( American Society for Biochemistry and Molecular Biology , 2015 , Article)
Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived ...