College of Health Sciences: Recent submissions
Now showing items 1121-1140 of 1729
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Predicting hypertension using machine learning: Findings from Qatar Biobank Study
( PLoS ONE , 2020 , Article)Hypertension, a global burden, is associated with several risk factors and can be treated by lifestyle modifications and medications. Prediction and early diagnosis is important to prevent related health complications. The ... -
Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach
( Taylor and Francis , 2020 , Article)K-Ras is a small GTPase and acts as a molecular switch by recruiting GEFs and GAPs, and alternates between the inert GDP-bound and the dynamic GTP-bound forms. The amino acid at position 12 of K-Ras is a hot spot for ... -
Vaccine Development Against COVID-19 Prior to Pandemic Outbreaks, Using in vitro Evolution and Reverse Genetics
( Frontiers Media , 2020 , Article)Developing vaccines against COVID-19 during or after future pandemic outbreaks will be too slow to save lives. The opinion presented here is that we can anticipate the virus genomic structures that will emerge and cause ... -
Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia
( Elsevier , 2020 , Article)Propionic Acidemia (PA) is an inborn error of metabolism caused by variants in the or genes, leading to mitochondrial accumulation of propionyl-CoA and its by-products. Here, we report a 2 year-old Egyptian boy with PA ... -
Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles.
( Nature Research , 2020 , Article)Gallic acid (GA) is a natural phenolic compound with therapeutic effects that are often challenged by its rapid metabolism and clearance. Therefore, GA was encapsulated using gum arabic into nanoparticles to increase its ... -
Formulation, Cellular Uptake and Cytotoxicity of Thymoquinone-Loaded PLGA Nanoparticles in Malignant Melanoma Cancer Cells
( Dove Medical Press , 2020 , Article)Introduction: Thymoquinone (TQ) is the main active compound extracted from Nigella sativa a traditional herb with wide therapeutic applications and recognizable anticancer properties. This study aimed to formulate and ... -
"It's disappointing and it's pretty frustrating, because it feels like it's something that will never go away." A qualitative study exploring individuals' beliefs and experiences of Achilles tendinopathy.
( Public Library of Science , 2020 , Article)Achilles tendinopathy (AT) is a common and often persistent musculoskeletal disorder affecting both athletic and non-athletic populations. Despite the relatively high incidence there is little insight into the impact and ... -
Lower Limb Kinetic Asymmetries in Professional Soccer Players With and Without Anterior Cruciate Ligament Reconstruction: Nine Months Is Not Enough Time to Restore "Functional" Symmetry or Return to Performance
( SAGE Publications , 2020 , Article)Residual between-limb deficits are a possible contributing factor to poor outcomes in athletic populations after anterior cruciate ligament reconstruction (ACLR). Comprehensive appraisals of movement strategies utilized ... -
Why do tendon researchers overlook the patient's psychological state? The review with no papers.
( BMJ Publishing Group , 2020 , Article)Exercise or loading interventions remain the conservative treatment of choice in the management of tendinopathy.1 However, as many as 60% of individuals experience continued symptoms, while up to a quarter of patients ... -
Better reporting standards are needed to enhance the quality of hop testing in the setting of ACL return to sport decisions: a narrative review.
( BMJ Publishing Group , 2020 , Article Review)There is a lack of consistency in return to sport (RTS) assessments, in particular hop tests to predict who will sustain a reinjury following anterior cruciate ligament (ACL) reconstruction. Inconsistent test battery content ... -
Implementing 360 Quantified Self for childhood obesity: Feasibility study and experiences from a weight loss camp in Qatar
( BioMed Central Ltd. , 2017 , Article)Background: The explosion of consumer electronics and social media are facilitating the rise of the Quantified Self (QS) movement where millions of users are tracking various aspects of their daily life using social media, ... -
Concurrent validity and within-session reliability of gait kinematics measured using an inertial motion capture system with repeated calibration
( Elsevier , 2020 , Article)IntroductionWearable inertial measurement units (IMUs) enable gait analysis in the clinic, but require calibrations that may affect subsequent gait measurements. This study assessed concurrent validity and within-session ... -
Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
( Wiley , 2020 , Article)© 2020 Wiley Periodicals, Inc. Myosin-binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical ... -
Dietary patterns and glycaemic control among Qatari adults with type 2 diabetes.
( Cambridge University Press , 2020 , Article)To assess the association between dietary patterns and glycaemic control among Qatari adults with type 2 diabetes (T2DM). Cross-sectional analysis using data from the Qatar Biobank Study. Poor glycaemic control was defined ... -
Growing Burden of Hypertension in China: Causes, Challenges, and Opportunities
( Chinese Center for Disease Control and Prevention (China CDC) , 2020 , Article Review)Cardiovascular disease (CVD) is the leading cause of death in China, and an estimated 290 million individuals are affected by CVD in China (1). Hypertension is the most important risk factor of CVD (2). Good control ... -
Changes in preventive care utilisation and its influencing factors among Chinese adults before and after the healthcare reform: cross-sectional evidence from the China Health and Nutrition Survey in 2004-2015.
( BMJ Publishing Group Ltd , 2020 , Article)China launched its health reform in 2009. This study aimed to assess changes in preventive care utilisation (PCU) and its relationship with the healthcare reform. A cross-sectional study using demographic characteristics, ... -
Cardiovascular Risk Among Patients ≥ 65 Years of Age with Parkinson's Disease (From the National Inpatient Sample)
( Elsevier , 2020 , Article)In this study, we aimed to investigate the relationship between PD and vascular disease and risk factors using a nationally representative sample. The National Inpatient Sample (NIS) was queried for all patients aged ≥ 65 ... -
Taxane formulations: From plant to clinic
( Springer International Publishing , 2017 , Book chapter)Taxanes including paclitaxel and docetaxel are highly active against many types of cancers. The main obstacle with developing delivery systems of taxanes is their poor water solubility. In this chapter, taxanes were reviewed ... -
Willingness to participate in genome testing: a survey of public attitudes from Qatar
( Springer , 2020 , Article)Genomics has the potential to revolutionize medical approaches to disease prevention, diagnosis, and treatment, but it does not come without challenges. The success of a national population-based genome program, like the ... -
Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion
( Wiley Open Access , 2020 , Article)Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%-10% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting the ...
