College of Health Sciences: Recent submissions
Now showing items 1441-1460 of 1696
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Pulse versus daily oral Alfacalcidol treatment of secondary hyperparathyroidism in hemodialysis patients: a randomized controlled trial.
( Dove Medical Press , 2018 , Article)Secondary hyperparathyroidism is a common complication of chronic kidney disease and is managed using vitamin D replacement therapy. Very few studies have examined the effectiveness of pulse alfacalcidol therapy in comparison ... -
Effect of a robotic seal on the motor activity and sleep patterns of older people with dementia, as measured by wearable technology: A cluster-randomised controlled trial
( Elsevier , 2018 , Article)Abstract ObjectivesThe robotic seal, PARO, has been used as an alternative to animal-assisted therapies with residents with dementia in long-term care, yet understanding of its efficacy is limited by a paucity of research. ... -
P3. 210 Estimating the antibody prevalence of herpes simplex virus type 2 among select middle east and north africa populations
( BMJ Publishing Group , 2017 , Conference Proceedings)Introduction There are very limited data on herpes simplex virus type 2 (HSV-2) infection in the Middle East and North Africa (MENA). We examined the overall and age-specific HSV-2 antibody prevalence among select MENA ... -
CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion.
(2017 , Article)We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate signaling ... -
Substitution impact of highly conserved arginine residue at position 75 in GJB1 gene in association with X-linked Charcot-Marie-tooth disease: A computational study.
( Elsevier , 2018 , Article)X-linked Charcot-Marie-Tooth type 1 X (CMTX1) disease is a subtype of Charcot-Marie-Tooth (CMT), which is mainly caused by mutations in the GJB1 gene. It is also known as connexin 32 (Cx32) that leads to Schwann cell ... -
A profound computational study to prioritize the disease-causing mutations in PRPS1 gene.
( Springer Verlag , 2017 , Article)Charcot-Marie-Tooth disease (CMT) is one of the most commonly inherited congenital neurological disorders, affecting approximately 1 in 2500 in the US. About 80 genes were found to be in association with CMT. The phosphoribosyl ... -
Differences in the neovascular potential of thymus versus subcutaneous adipose-derived stem cells from patients with myocardial ischemia.
( Wiley , 2017 , Article)Adipose tissue-derived multipotent mesenchymal cells (ASCs) participate in the formation of blood vessels under hypoxic conditions. It is probable that the susceptibility of ASCs to the influence of age and aging-associated ... -
Structural modeling of p.V31F variant in the aspartoacylase gene.
( Springer Verlag , 2016 , Article)Aspartoacylase (ASPA) is an abundant enzyme in the brain, which catalyzes the conversion of N-acetylaspartate into acetate and aspartate, deficiency in its activity leads to degeneration of the white matter of the brain ... -
Epidemiology of diabetic ketoacidosis in Arab patients with type 1 diabetes: a systematic review.
( Wiley , 2016 , Article)Diabetic ketoacidosis (DKA) is an acute and risky complication of type 1 diabetes. The aim of this study is to build the overall rate of DKA in Arab patients with type 1 diabetes in the 22 Arab nations. This is expected ... -
Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope
( Elsevier (Cell Press) , 2017 , Article)The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies ... -
Evaluation of Global Genomic DNA Methylation in Human Whole Blood by Capillary Electrophoresis UV Detection
( Hindawi Publishing Corporation , 2017 , Article)Alterations in global DNA methylation are implicated in various pathophysiological processes. The development of simple and quick, yet robust, methods to assess DNA methylation is required to facilitate its measurement and ... -
Maternal microbiota regulate glucocorticoids levels and placental development in mice
( bioscientifica , 2015 , Conference Proceedings)The gut microbiota contributes to postnatal development and maturation by influencing barrier functions of the intestinal wall, the development of the immune system, and the utilisation of nutrients. Recent studies have ... -
Using a therapeutic companion robot for dementia symptoms in long-term care: reflections from a cluster-RCT.
( Taylor & Francis (Routledge) , 2017 , Article)We undertook a cluster-randomised controlled trial exploring the effect of a therapeutic companion robot (PARO) compared to a look-alike plush toy and usual care on dementia symptoms of long-term care residents. Complementing ... -
Meta-analysis in evidence-based healthcare: a paradigm shift away from random effects is overdue.
( University of Adelaide, Joanna Briggs Institute , 2017 , Article)Each year up to 20 000 systematic reviews and meta-analyses are published whose results influence healthcare decisions, thus making the robustness and reliability of meta-analytic methods one of the world's top clinical ... -
Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism
( Nature Publishing Group in partnership with Nanyang Technological University , 2016 , Article)The ligand-induced transcription factor, aryl hydrocarbon receptor (AhR) is known for its capacity to tune adaptive immunity and xenobiotic metabolism-biological properties subject to regulation by the indigenous microbiome. ... -
PopPAnTe: population and pedigree association testing for quantitative data.
( BioMed Central , 2017 , Article)Family-based designs, from twin studies to isolated populations with their complex genealogical data, are a valuable resource for genetic studies of heritable molecular biomarkers. Existing software for family-based studies ... -
Dietary patterns and the risk of coronary heart disease among Jordanians: A caseecontrol study
( Elsevier , 2017 , Article)Background and Aims Dietary pattern and lifestyle have been reported to be significant risk factors in the development of coronary heart diseases (CHD). The contribution degree of these dietary risk factors in CHD ... -
Accredited genetic testing in the Arab Gulf region: reinventing the wheel.
( Nature Publishing Group , 2016 , Article)Accredited genetic testing in the Arab Gulf region: reinventing the wheel. -
Genetic Epidemiology of Type 1 Diabetes in the 22 Arab Countries.
( Current Medicine Group , 2016 , Article)Type 1 diabetes (T1D) is a complex autoimmune disorder that results from the T cell-mediated destruction of the pancreatic β cells and is due to interactions between environmental and genetic factors. Although Arabs have ... -
Two patients with Canavan disease and structural modeling of a novel mutation.
( Springer US , 2017 , Article)Canavan disease (CD) is a rare fatal childhood neurological autosomal recessive genetic disease caused by mutations in the ASPA gene, which lead to catalytic deficiency of the ASPA enzyme, which catalyzes the hydrolysis ...