College of Health Sciences: Recent submissions
Now showing items 201-220 of 1726
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Breaking Barriers: The Promise and Challenges of Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with pronounced immunogenicity, exhibiting rapid proliferation and immune cell infiltration into the tumor microenvironment. TNBC’s heterogeneity poses ... -
"I am not the same as before": a mixed-methods study on depression in people with spinal injury in Qatar
( Frontiers Media SA , 2024 , Article)Incidence of spinal injury is high in the Middle East and North African region (MENA) due to the high incidence of road traffic crashes. A spinal injury may trigger mental health issues. Compared to the general population, ... -
Dietary Patterns and Hypothyroidism in U.S. Adult Population
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The thyroid gland produces hormones that are essential for various body functions. Hypothyroidism is defined as insufficient thyroid hormone production. Several studies have found associations between specific micronutrients ... -
An insight into the clinical learning environment of dental institutes: a study in the twin cities of Pakistan
( Pakistan Medical Association , 2024 , Article)Objective: To assess the perceptions of dental students regarding their clinical learning environment in an urban setting. Method: This descriptive, cross-sectional survey was conducted from March 2020 to May 2021 after ... -
Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties
( IOP Publishing , 2024 , Article)Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being ... -
In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model
( Elsevier , 2024 , Article)Heart failure (HF) is a multifactorial, heterogeneous systemic disease that is considered one of the leading causes of death and morbidity worldwide. It is well-known that endothelial dysfunction (ED) plays an important ... -
The Association between Lifestyle Factors and COVID-19: Findings from Qatar Biobank.
( MDPI , 2024 , Article)Coronavirus Disease 2019 (COVID-19) manifestations range from mild to severe life-threatening symptoms, including death. COVID-19 susceptibility has been associated with various factors, but studies in Qatar are limited. ... -
In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer
( International Institute of Anticancer Research , 2014 , Article)Previously, our laboratory reported on novel quinuclidinone derivatives that cause cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299). The current study aims to investigate the effect of ... -
Biological and biomedical functions of Penta-O-galloyl-D-glucose and its derivatives
( Springer Nature , 2014 , Article Review)Penta-O-galloyl-D-glucose (PGG) is a simple hydrolysable tannin in plants. PGG exists in two anomeric forms, α-PGG and β-PGG. While β-PGG can be found in a wide variety of plants, α-PGG is rather rare in nature. Numerous ... -
Glucose- and triglyceride-lowering dietary penta-O-galloyl-α-D-glucose reduces expression of PPARγ and C/EBPα, induces p21-Mediated G1 phase cell cycle arrest, and inhibits adipogenesis in 3T3-L1 preadipocytes
( Thieme , 2015 , Article)Plant polyphenols, such as hydrolysable tannins, are present in the human diet and known to exhibit anti-diabetic and anti-obesity activity. We previously reported that the representative hydrolysable tannin compound ... -
Novel thiosemicarbazides induced apoptosis in human MCF-7 breast cancer cells via JNK signaling
( Taylor & Francis , 2015 , Article)In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound ... -
Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study
( Frontiers Media SA , 2024 , Article)Background: Metformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim ... -
The effect of novel nitrogen-based chalcone analogs on colorectal cancer cells: Insight into the molecular pathways
( Elsevier , 2024 , Article)In colorectal cancer (CRC), aberrations in KRAS are associated with aggressive tumorigenesis and an overall low survival rate because of chemoresistance and adverse effects. Ergo, complementary, and integrative medicines ... -
Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance (Molecular Cancer, (2020), 19, 1, (57), 10.1186/s12943-020-01175-9)
( BMC , 2020 , Article)Following the publication of the original article [1], authors have noticed that one of the authors, Syed Shadab Raza, was missing in the Authors’ Contributions section. Please see below updated section. -
Forging the Path to Precision Medicine in Qatar: A Public Health Perspective on Pharmacogenomics Initiatives
( Frontiers Media , 2024 , Article Review)Pharmacogenomics (PGx) is an important component of precision medicine that promises tailored treatment approaches based on an individual’s genetic information. Exploring the initiatives in research that help to integrate ... -
Sugar-sweetened beverage intakes among adults between 1990 and 2018 in 185 countries
(2023 , Article)Sugar-sweetened beverages (SSBs) are associated with cardiometabolic diseases and social inequities. For most nations, recent estimates and trends of intake are not available; nor variation by education or urbanicity. We ... -
Dietary Intake Is Not Associated with Body Composition nor with Biochemical Tests but with Psychological Status of Cancer Patients Receiving Chemotherapy
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Chemotherapy can negatively affect cancer patients’ eating patterns, psychological status, body composition, and quality of life. In this study, we aimed to investigate the correlations between dietary intake/care and the ... -
Factors Affecting Healthcare Provider Referral to Heart Function Clinics: A Mixed-Methods Study
( Wolters Kluwer Health , 2024 , Article)Background Heart failure (HF) care providers are gatekeepers for patients to appropriately access lifesaving HF clinics. Objective The aim of this study was to investigate referring providers' perceptions regarding referral ... -
The role of genetic and epigenetic GNAS alterations in the development of early-onset obesity
( Elsevier , 2023 , Article)BackgroundGNAS (guanine nucleotide-binding protein, alpha stimulating) is an imprinted gene that encodes Gsα, the α subunit of the heterotrimeric stimulatory G protein. This subunit mediates the signalling of a diverse ... -
Impact of emotional intelligence in resolving clinical conflicts among postgraduate residents of surgery
( Professional Medical Publications , 2023 , Article)Background & Objective: Emotional intelligence (EI) can become a vital tool for resolving clinical conflicts (CC) in surgery. The postgraduate residents focus on the technical skills and undermine the soft skills required ...
