Biomedical Sciences
Recent Submissions
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Evaluating chemiluminescent immunoassays for syphilis detection: A comparative analysis
( Elsevier , 2025 , Article)BackgroundSyphilis, caused by Treponema pallidum (TP), remains a significant global public health concern, with approximately 8 million new cases annually. Diagnosing syphilis is challenging due to its often-asymptomatic ... -
Evaluating Hospital Admission Data as Indicators of COVID-19 Severity: A National Assessment in Qatar.
( Oxford University Press , 2025 , Article)Accurately assessing SARS-CoV-2 infection severity is essential for understanding the health impact of the infection and evaluating the effectiveness of interventions. This study investigated whether SARS-CoV-2-associated ... -
Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells
( Springer Nature , 2025 , Article)Background: Cancer cells can modulate the expression of many proteins that are essential for supporting their uncontrolled proliferation. Heat shock protein 90 (HSP90) is ubiquitously expressed in most cell types and ... -
The molecular mechanism of nitric oxide in memory consolidation and its role in the pathogenesis of memory-related disorders
( Springer Nature , 2025 , Article)Memory is a dynamic process of encoding, storing, and retrieving information. It includes sensory, short-term, and long-term memory, each with unique characteristics. Nitric oxide (NO) is a biological messenger synthesized ... -
Indications and clinical outcomes of percutaneous cholecystostomies in acute cholecystitis: a study from Qatar.
( BioMed Central , 2025 , Article)Acute cholecystitis (AC) is a prevalent condition in emergency departments (EDs). Standard care involves early laparoscopic cholecystectomy; however, in cases of delayed presentation, high surgical risk, or during situations ... -
Advancing Medical Research Through Artificial Intelligence: Progressive and Transformative Strategies: A Literature Review
( John Wiley & Sons , 2025 , Article)Background and Aims: Artificial intelligence (AI) has become integral to medical research, impacting various aspects such as data analysis, writing assistance, and publishing. This paper explores the multifaceted influence ... -
Seroprevalence of influenza A H1N1 and influenza D viruses in ruminants in Qatar
( Elsevier , 2025 , Article)BackgroundInfluenza is among the most common viruses affecting humans and many animals worldwide. While influenza A (IAV) and D (IDV) viruses are associated with respiratory disease in humans and animals, respectively, ... -
Association between clinical laboratory indicators and WOMAC scores in Qatar Biobank participants: The impact of testosterone and fibrinogen on pain, stiffness, and functional limitation
( Walter de Gruyter GmbH , 2025 , Article)Objectives: The association between baseline laboratory parameters and experienced well-being in healthy individuals remains uncertain. This study explored the relationship between clinical laboratory profiles and Western ... -
Unveiling GATA3 Signaling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic Potential
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)GATA binding protein 3 (GATA3), a member of the GATA family transcription factors, is a key player in various physiological and pathological conditions. It is known for its ability to bind to the DNA sequence "GATA", which ... -
Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce eNOS phosphorylation in vascular endothelial cells
( Nature Research , 2024 , Article)Diabetes mellitus is a chronic disease characterized by metabolic defects, including insulin deficiency and resistance. Individuals with diabetes are at increased risk of developing cardiovascular complications, such as ... -
Metabarcoding analysis of oral microbiome during pregnancy
( Frontiers Media SA , 2024 , Article)Pregnancy is a dynamic physiological process involving significant hormonal, immune, and metabolic changes to support fetal growth and development. This study investigates the changes in salivary microbiome and biochemical ... -
Prevalence of SPOP and IDH Gene Mutations in Prostate Cancer in a Jordanian Population
( Springer , 2024 , Article)Speckle-type POZ (SPOP) is described as an essential tumor suppressor factor in gastric cancer, colorectal cancer, and prostate cancer (PCa). SPOP gene mutations were reported in primary human PCa. Isocitrate dehydrogenase-1 ... -
GATA3: Orchestrating cellular fate through differentiation and proliferation
( Elsevier , 2025 , Article Review)Cell proliferation and differentiation are two fundamental biological processes that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). Zinc finger proteins are TFs ... -
Mindray CL-900i assay: An effective assay for hepatitis B surface antigen screening with superior specificity
( Elsevier , 2025 , Article)Objectives The chemiluminescence immunoassay automated Abbott ARCHITECT hepatitis B surface antigen (HBsAg) screening assay is globally recognized for its superior sensitivity but notably low specificity. This mandates ... -
Molecular identification and characterization of waterborne protozoa among stranded Dugong dugon
( Elsevier , 2025 , Article)The Persian Gulf hosts the second-largest population of Dugongs. The International Union for the Conservation of Nature (IUCN) lists them as Vulnerable to Extinction species. Incidental fishing, vessel strikes, environmental ... -
Chapter Seven Exploring the effect of disease causing mutations in metal binding sites of human ARSA in metachromatic leukodystrophy
( Elsevier , 2024 , Book chapter)The arylsulfatase A (ARSA) gene is observed to be deficient in patients with metachromatic leukodystrophy (MLD), a type of lysosomal storage disease. MLD is a severe neurodegenerative disorder characterized by an autosomal ... -
Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar
( Elsevier , 2025 , Article)Breast cancer is a global health concern, including in Qatar, where it impacts women significantly. The complexity of breast cancer requires diverse treatment approaches influenced by tumor characteristics and biology. ... -
Advances in Huntington’s Disease Biomarkers: A 10-Year Bibliometric Analysis and a Comprehensive Review
( MDPI , 2025 , Article Review)Neurodegenerative disorders (NDs) cause progressive neuronal loss and are a significant public health concern, with NDs projected to become the second leading global cause of death within two decades. Huntington’s disease ... -
Universal Genetic Testing for Newly Diagnosed Invasive Breast Cancer
( American Medical Association , 2024 , Article)IMPORTANCE Between 5% and 10% of breast cancer cases are associated with an inherited germline pathogenic or likely pathogenic variant (GPV) in a breast cancer susceptibility gene (BCSG), which could alter local and systemic ... -
In vivo assessment of the nephrotoxic effects of the synthetic cannabinoid AB-FUBINACA
( Springer , 2024 , Article)Background: The widespread misuse of synthetic cannabinoids (SCs) has led to a notable increase in reported adverse effects, raising significant health concerns. SCs use has been particularly associated with acute kidney ...
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