تصفح Biomedical Sciences حسب المؤلف "S., Udhaya Kumar"
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Comparison of potential inhibitors and targeting fat mass and obesity-associated protein causing diabesity through docking and molecular dynamics strategies.
S, Udhaya Kumar; Rajan, Bithia; D, Thirumal Kumar; R, Hephzibah Cathryn; V, Samprita Das.; Zayed, Hatem; Walter, Charles Emmanuel Jebaraj; Ramanathan, Gnanasambandan; Doss, George Priya... more authors ... less authors ( Wiley , 2021 , Article)Genome-wide association studies (GWAS) have identified an association between polymorphisms in the FTO gene and obesity. The FTO: rs9939609, an intronic variant, is considered a risk allele for developing diabesity in ... -
Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach.
S, Udhaya Kumar; Sankar, Srivarshini; Younes, Salma; D, Thirumal Kumar; Ahmad, Muneera Naseer; Okashah, Sarah Samer; Kamaraj, Balu; Al-Subaie, Abeer Mohammed; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( MDPI , 2020 , Article)Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved ... -
An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia
S, Udhaya Kumar; D, Thirumal Kumar; R, Siva; C, George Priya Doss; Zayed, Hatem ( Elsevier , 2019 , Article)Type I galactosemia is a very rare autosomal recessive genetic metabolic disorder that occurs because of the mutations present in the galactose-1-phosphate uridyl transferase (GALT) gene, resulting in a deficiency of the ... -
Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach.
Thirumal Kumar, D; Jain, Nikita; S, Udhaya Kumar; GeorgePriya Doss, C; Zayed, Hatem ( Taylor & Francis , 2019 , Article)The autosomal recessive phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is characterized by defective functioning of the PMM2 enzyme, which is necessary for the conversion of mannose-6-phosphate into ... -
Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity
S, Udhaya Kumar; Rajan, Bithia; D, Thirumal Kumar; V, Anu Preethi; Abunada, Taghreed; Younes, Salma; Okashah, Sarah; Ethiraj, Selvarajan; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( MDPI , 2020 , Article)(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of premature heart attack, stroke, and death. To date, a key challenge has ... -
Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach
S, Udhaya Kumar; R, Bithia; D, Thirumal Kumar; Doss, C George Priya; Zayed, Hatem ( Taylor and Francis , 2020 , Article)K-Ras is a small GTPase and acts as a molecular switch by recruiting GEFs and GAPs, and alternates between the inert GDP-bound and the dynamic GTP-bound forms. The amino acid at position 12 of K-Ras is a hot spot for ...