تصفح Biomedical Sciences حسب المؤلف "Yassin, Mohamed A."
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Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar
Ismail, Mohamed A; Samara, Muthanna; Al Sayab, Ali; Alsharshani, Mohamed; Yassin, Mohamed A; Varadharaj, Govindarajulu; Vezzalini, Marzia; Tomasello, Luisa; Monne, Maria; Morsi, Hisham; Qoronfleh, M Walid; Zayed, Hatem; Cook, Richard; Sorio, Claudio; Modjtahedi, Helmout; Al-Dewik, Nader I... more authors ... less authors ( Wiley Open Access , 2020 , Article)Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated ... -
Clinical Exome Sequencing unravels new disease-causing mutations in the myeloproliferative neoplasms: A pilot study in patients from the state of Qatar.
Al-Dewik, Nader; Ben-Omran, Tawfeg; Zayed, Hatem; Trujillano, Daniel; Kishore, Shivendra; Rolfs, Arndt; Yassin, Mohamed A... more authors ... less authors ( Elsevier , 2018 , Article)Clinical Exome Sequencing (CES) has increasingly become a popular diagnostic tool in patients suffering from genetic disorders that are clinically and genetically complicated. Myeloproliferative Neoplasms (MPNs) is an ... -
Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors
Mohamed A., Ismail; Nasrallah, Gheyath K.; Monne, Maria; AlSayab, Ali; Yassin, Mohamed A.; Varadharaj, Govindarajulu; Younes, Salma; Sorio, Claudio; Cook, Richard; Modjtahedi, Helmout; Al-Dewik, Nader I.... more authors ... less authors ( Elsevier , 2022 , Article)Tyrosine kinase inhibitors (TKIs) have remarkably transformed Ph+ chronic myeloid leukemia (CML) management; however, TKI resistance remains a major clinical challenge. Mutations in BCR-ABL1 are well studied but fail to ... -
Distinct Clinical and Prognostic Features of Myelodysplastic Syndrome in Patients from the Middle East, North Africa, and Beyond: A Systemic Review
Al-Haidose, Amal; Yassin, Mohamed A.; Ahmed, Muna N.; Kunhipurayil, Hasna H.; Al-Harbi, Asrar A.; Aljaberi, Musheer A.; Abbasi, Saddam A.; Kordasti, Shahram; Abdallah, Atiyeh M.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Myelodysplastic syndrome (MDS) describes a group of bone marrow malignancies with variable morphologies and heterogeneous clinical features. The aim of this study was to systematically appraise the published clinical, ...