Browsing Biomedical Sciences by Author "Kamareddine, Layla"
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Advances in Cardiovascular Biomarker Discovery.
Ghantous, Crystal M; Kamareddine, Layla; Farhat, Rima; Zouein, Fouad A; Mondello, Stefania; Kobeissy, Firas; Zeidan, Asad... more authors ... less authors ( MDPI , 2020 , Article Review)Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart ... -
Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling
Kamareddine, Layla; Ghantous, Crystal; Allouch, Soumaya; Al-Ashmar, Sara; Anlar, Gulsen; Kannan, Surya; Djouhri, Laiche; Korashy, Hesham; Agouni, Abdelali; Zeidan, Asad... more authors ... less authors ( Dove Medical Press , 2021 , Article Review)Cardiac remodeling is the process by which the heart adapts to stressful stimuli, such as hypertension and ischemia/reperfusion; it ultimately leads to heart failure upon long- term exposure. Autophagy, a cellular catabolic ... -
COVID-19 Vaccination: The Mainspring of Challenges and the Seed of Remonstrance
Najjar, Hoda; Al-Jighefee, Hadeel T.; Qush, Abeer; Ahmed, Muna N.; Awwad, Sara; Kamareddine, Layla... more authors ... less authors ( MDPI , 2021 , Article Review)As of March 2020, the time when the coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic, our existence has been threatened and the lives of ... -
COVID-19 Vaccine Platforms: Challenges and Safety Contemplations
Al-Jighefee, Hadeel; Najjar, Hoda; Ahmed, Muna; Qush, Abeer; Awwad, Sara; Kamareddine, Layla... more authors ... less authors ( MDPI , 2021 , Article Review)The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic as of March 2020, creating a global crisis and claiming millions of lives. To halt the pandemic and alleviate its impact on society, ... -
Drosophila as a Model Organism in Host–Pathogen Interaction Studies
Younes, Salma; Al-Sulaiti, Asma; Abdulwahab Ahmed Nasser, Elham; Najjar, Hoda; Kamareddine, Layla ( Frontiers Media , 2020 , Article Review)Owing to the genetic similarities and conserved pathways between a fruit fly and mammals, the use of the Drosophila model as a platform to unveil novel mechanisms of infection and disease progression has been justified and ... -
Editorial: Unconventional Animal Models in Infectious Disease Research
Kamareddine, Layla ( Frontiers Media , 2021 , Other)Beyond an in vitro setting, the use of a biological system is considered imperious to unravel the enigma of host-pathogen interactions, particularly those eventuating in an infectious disease scenery. In the past two-decades, ... -
Editorial: Unconventional animal models in infectious disease research, volume II
Younes, Salma; Zein, Nouran; Abunasser, Shaden; Kamareddine, Layla; Kirienko, Natalia V.; Nasrallah, Gheyath K.... more authors ... less authors ( Frontiers Media , 2023 , Other)Infectious diseases remain a serious health threat globally, an actuality that necessitates ongoing research in this field. Among different research modalities, the use of animal models to unravel host-pathogen interactions ... -
The effect of novel nitrogen-based chalcone analogs on colorectal cancer cells: Insight into the molecular pathways
Arij Fouzat, Hassan; Hussein, Ola; Al-Barazenji, Tara; Allouch, Asma; Kamareddine, Layla; Malki, Ahmed; Moustafa, Ala‐Eddin Al; Khalil, Ashraf... more authors ... less authors ( Elsevier , 2024 , Article)In colorectal cancer (CRC), aberrations in KRAS are associated with aggressive tumorigenesis and an overall low survival rate because of chemoresistance and adverse effects. Ergo, complementary, and integrative medicines ... -
Enteric pathogens modulate metabolic homeostasis in the Drosophila melanogaster host
Hoda, Najjar; Al-Ashmar, Sarah; Qush, Abeer; Al-Asmar, Jawaher; Rashwan, Sara; Elgamal, Abdelrahman; Zeidan, Asad; Kamareddine, Layla... more authors ... less authors ( Elsevier , 2022 , Article)On quotidian basis, living beings work out an armistice with their microbial flora and a scuffle with invading pathogens to maintain a normal state of health. Although producing virulence factors and escaping the host's ... -
The Impact of Environmental and Anthropogenic Factors on the Transmission Dynamics of Vector Borne Diseases
Kamareddine, Layla ( Elsevier , 2019 , Article)Vector-borne diseases have been widely associated with human morbidity and mortality. The predominance of vector-borne diseases is not exclusive to particular areas, as such diseases are dispersed across the globe. Generally, ... -
Involvement of caveolae in hyperglycemia-induced changes in adiponectin and leptin expressions in vascular smooth muscle cells
Ola, El Atab; Ghantous, Crystal M.; El-Zein, Nabil; Farhat, Rima; Agouni, Abdelali; Korashy, Hesham M.; Djouhri, Laiche; Kamareddine, Layla; Zibara, Kazem; Zeidan, Asad... more authors ... less authors ( Elsevier , 2021 , Article)Hyperglycemia exerts various harmful effects on the vasculature. Studies have shown an association between the levels of the adipokines leptin and adiponectin (APN) and vascular complications in diabetes mellitus. The aim ... -
The Microbiota and Gut-Related Disorders: Insights from Animal Models
Kamareddine, Layla; Najjar, Hoda; Abdulkader, Hadil; Al-Asmakh, Maha; Sohail, Muhammad Umar ( MDPI , 2020 , Article Review)Over the past decade, the scientific committee has called for broadening our horizons in understanding host–microbe interactions and infectious disease progression. Owing to the fact that the human gut harbors trillions ... -
Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex
Bat-Erdene, Jugder; Kamareddine, Layla; Watnick, Paula I. ( Elsevier , 2021 , Article)Microbe-derived acetate activates the Drosophila immunodeficiency (IMD) pathway in a subset of enteroendocrine cells (EECs) of the anterior midgut. In these cells, the IMD pathway co-regulates expression of antimicrobial ... -
The mosquito melanization response requires hierarchical activation of non-catalytic clip domain serine protease homologs.
El Moussawi, Layla; Nakhleh, Johnny; Kamareddine, Layla; Osta, Mike ( Public Library of Science , 2019 , Article)Serine protease cascades regulate important insect immune responses namely melanization and Toll pathway activation. An important component of these cascades are clip-domain serine protease homologs (cSPHs), which are ... -
SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections
Farhan, Cyprian; Sohail, Muhammad Umar; Abdelhafez, Ibrahim; Salman, Salma; Attique, Zakria; Kamareddine, Layla; Al-Asmakh, Maha... more authors ... less authors ( Elsevier , 2021 , Article)By the beginning of 2020, infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had rapidly evolved into an emergent worldwide pandemic, an outbreak whose unprecedented consequences highlighted ... -
UNCONVENTIONAL ANIMAL MODELS IN INFECTIOUS DISEASE RESEARCH
Nasrallah, Gheyath Khaled; Kamareddine, Layla; Baddal, Buket ( Frontiers , 2021 , E-Book)Apart from genetics and physiology, our understanding of other important aspects of the biological life, such as host-pathogen interactions stayed at its infancy for many years. Back then, many infectious diseases lacked ...