تصفح Biomedical Sciences حسب المؤلف "Udhaya Kumar, S"
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Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach.
Udhaya Kumar, S; Thirumal Kumar, D; Bithia, R; Sankar, Srivarshini; Magesh, R.; Sidenna, Mariem; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Frontiers Media , 2020 , Article)Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on identifying the dysregulated molecular pathways and core genes ... -
Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene.
Udhaya Kumar, S; Thirumal Kumar, D; Mandal, Pinky D; Sankar, Srivarshini; Haldar, Rishin; Kamaraj, Balu; Walter, Charles Emmanuel Jebaraj; R, Siva; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2020 , Article)Sjögren-Larsson syndrome (SLS) is an autoimmune disorder inherited in an autosomal recessive pattern. To date, 80 missense mutations have been identified in association with the Aldehyde Dehydrogenase 3 Family Member A2 ... -
Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome.
Thirumal Kumar, D; Udhaya Kumar, S; Nishaat Laeeque, Ahmed Shaikh; Apurva Abhay, Shivalkar; Bithia, R; Magesh, R.; Kumar, Maignana; Zayed, Hatem; George Priya Doss, C... more authors ... less authors ( Elsevier , 2020 , Article)Blau syndrome (BS), which affects the eyes, skin, and joints, is an autosomal dominant genetic inflammatory disorder. BS is caused by mutations in the NOD2 gene. However, there are no direct treatments, and treatment with ... -
Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients - A Bioinformatics Approach.
Udhaya Kumar, S; Thirumal Kumar, D; Siva, R; George Priya Doss, C; Younes, Salma; Younes, Nadin; Sidenna, Mariem; Zayed, Hatem... more authors ... less authors ( Frontiers Media , 2020 , Article)Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder that is clinically complex and has increased production of autoantibodies. Via emerging technologies, researchers have identified genetic variants, ... -
Molecular dynamics simulations to decipher the structural and functional consequences of pathogenic missense mutations in the galactosylceramidase (GALC) protein causing Krabbe's disease.
Thirumal Kumar, D; Jain, Nikita; Udhaya Kumar, S; Jena, Prangya Paramita; Ramamoorthy, Siva; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Taylor & Francis , 2020 , Article)Krabbe disease (KD), also known as globoid cell leukodystrophy disease, is an autosomal recessive lysosomal storage genetic disorder, which is caused by the deficiecncy of galactocerebrosidase (GALC) coding gene (). This ...