Browsing Biomedical Sciences by Author "Kamaraj, Balu"
Now showing items 1-4 of 4
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Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene.
Udhaya Kumar, S; Thirumal Kumar, D; Mandal, Pinky D; Sankar, Srivarshini; Haldar, Rishin; Kamaraj, Balu; Walter, Charles Emmanuel Jebaraj; R, Siva; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2020 , Article)Sjögren-Larsson syndrome (SLS) is an autoimmune disorder inherited in an autosomal recessive pattern. To date, 80 missense mutations have been identified in association with the Aldehyde Dehydrogenase 3 Family Member A2 ... -
A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer.
Thirumal Kumar, D; Jain, Nikita; Evangeline, Judith; Kamaraj, Balu; Siva, R; Zayed, Hatem; George Priya Doss, C... more authors ... less authors ( Elsevier , 2019 , Article)Breast cancer (BC) is the most commonly diagnosed cancer among females worldwide, and among the BC-associated mutations in various proteins, mutations in the RAC-alpha serine/threonine-protein kinase (AKT1) remain the most ... -
Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface
Thirumal Kumar, D.; Udhaya Kumar, S.; Jain, Nikita; Sowmya, Baviri; Balsekar, Kamakshi; Siva, R.; Kamaraj, Balu; Sidenna, Mariem; George Priya Doss, C.; Zayed, Hatem... more authors ... less authors ( Elsevier , 2022 , Book chapter)Breast cancer type 1 susceptibility protein (BRCA1) is closely related to the BRCA2 (breast cancer type 2 susceptibility protein) and BARD1 (BRCA1-associated RING domain-1) proteins. The homodimers were formed through their ... -
Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach.
S, Udhaya Kumar; Sankar, Srivarshini; Younes, Salma; D, Thirumal Kumar; Ahmad, Muneera Naseer; Okashah, Sarah Samer; Kamaraj, Balu; Al-Subaie, Abeer Mohammed; C, George Priya Doss; Zayed, Hatem... more authors ... less authors ( MDPI , 2020 , Article)Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved ...