Biomedical Sciences: Recent submissions
Now showing items 1-20 of 789
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Curcumin as a novel therapeutic candidate for cancer: can this natural compound revolutionize cancer treatment?
( Frontiers Media SA , 2024 , Article Review)Cancer remains one of the leading causes of death worldwide. Despite advances in medical treatments, current therapeutic strategies, including radiotherapy, chemotherapy, targeted therapy, and surgical resection, have not ... -
Factor V Leiden (R506Q), Prothrombin G20210A, and MTHFR C677T Variants and Thrombophilia in Qatar Biobank Participants: A Case Control Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background: Thrombophilia, a predisposition to develop blood clots, is very common and can have serious sequelae. Aim: This study aimed to determine the prevalence of three thrombophilia-related genetic variants-factor V ... -
Hypoxic Stress Induces Complement-Mediated Lysis of Mesenchymal Stem Cells by Downregulating Factor H and CD59
( Korean Tissue Engineering and Regenerative Medicine Society , 2025 , Article)Background: Factor H and membrane inhibitor of reactive lysis (CD59) are key regulators of complement activation. Mesenchymal stem cells (MSCs) secrete Factor H and express CD59 to protect themselves from complement-mediated ... -
Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)Omega-3 polyunsaturated fatty acids (ω-3 PUFAs, n-3 PUFAs), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), are essential polyunsaturated fats primarily obtained from fatty ... -
Identification of novel hypertension biomarkers using explainable AI and metabolomics
( Springer , 2024 , Article)Background: The global incidence of hypertension, a condition of elevated blood pressure, is rising alarmingly. According to the World Health Organization's Qatar Hypertension Profile for 2023, around 33% of adults are ... -
Unraveling the proteomic signatures of coronary artery disease and hypercholesterolemia.
( The Association of Basic Medical Sciences , 2024 , Article)Atherosclerosis, a leading cause of coronary artery disease (CAD), is heavily influenced by hypercholesterolemia (HC). Proteomics research has shown promise in identifying biological markers for CAD diagnosis and prognosis. ... -
Inflammation-Modulating Biomedical Interventions for Diabetic Wound Healing: An Overview of Preclinical and Clinical Studies
( American Chemical Society , 2024 , Article Review)A diabetic wound exemplifies the challenge of chronic, nonhealing wounds. Elevated blood sugar levels in diabetes profoundly disrupt macrophage function, impairing crucial activities such as phagocytosis, immune response, ... -
Evaluating the Effects of BSA-Coated Gold Nanorods on Cell Migration Potential and Inflammatory Mediators in Human Dermal Fibroblasts
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Albumin-coated gold nanoparticles display potential biomedical applications, including cancer research, infection treatment, and wound healing; however, elucidating their interaction with normal cells remains an area with ... -
Enhancing Influenza Detection through Integrative Machine Learning and Nasopharyngeal Metabolomic Profiling: A Comprehensive Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background/Objectives: Nasal and nasopharyngeal swabs are commonly used for detecting respiratory viruses, including influenza, which significantly alters host cell metabolites. This study aimed to develop a machine learning ... -
Detached pyloric gland adenoma of gallbladder: A case report and review of literature.
( Wiley , 2024 , Article)Vigilant intraoperative inspection is crucial during gallbladder surgery to detect any abnormal tissue including the rare pyloric gland adenomas, which can be easily missed. Thorough examination and removal of unusual lymph ... -
Gut Microbiota–Tumor Microenvironment Interactions: Mechanisms and Clinical Implications for Immune Checkpoint Inhibitor Efficacy in Cancer
( Dove Medical Press , 2025 , Article)Cancer immunotherapy has transformed cancer treatment in recent years, with immune checkpoint inhibitors (ICIs) emerging as a key therapeutic approach. ICIs work by inhibiting the mechanisms that allow tumors to evade ... -
Computational insights into irinotecan's interaction with UBE2I in ovarian and endometrial cancers
( Elsevier , 2024 , Article)Endometrial and Ovarian cancers are two highly prevalent and fatal reproductive diseases with poor prognoses among women. Elevated estrogen levels in Ovarian Cancer (OC) stimulate the endometrium, causing Endometrial Cancer ... -
Association Between Vitamin D Receptor BsmI Polymorphism and Low Bone Mineral Density in Postmenopausal Women in the MENA Region
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background/Objectives: Low bone mineral density increases the risk of bone fractures, and this condition is especially common in postmenopausal women. Genetic factors significantly influence bone mineral density. This ... -
Seroprevalence and detection of Human herpesvirus-8 (HHV-8) among healthy blood donors residing in Qatar
( Elsevier , 2024 , Article)BackgroundHuman herpesvirus 8 (HHV-8) is a critical causative agent behind Kaposi sarcoma (KS), an oncogenic disease with profound consequences in immunocompromised individuals. Studies suggested HHV-8 seroprevalence in ... -
Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine
( Springer Nature , 2025 , Article)Background: Hypertension is a critical public health issue worldwide. The identification of specific proteomic biomarkers in the Qatari population aims to advance personalized treatment strategies. Methods: We conducted ... -
Efficient and regioselective synthesis of ortho-diiodinated homobenzylic alcohol derivatives: in silico evaluation as potential anticancer IDO/TDO inhibitors
( Royal Society of Chemistry , 2024 , Article)A simple and direct synthesis of 2,6-diiodophenylethanol building blocks through highly regioselective metalation (MIE)/oxirane SN2-type ring opening of 1,2,3-triiodobenzene is described. A significant impact of the nature ... -
The journey of female surgeons in the arab region: A scoping review
( Elsevier , 2024 , Article)BackgroundIn the Arab region, there's a dearth of research on female surgeons' experiences and challenges. To address this gap, a scoping review aims to map existing literature. It seeks to understand the hurdles faced by ... -
The Yemeni genetic structure revealed by the Y chromosome STRs
( Springer , 2025 , Article)Yemen, with its rich historical background and strategic geographical position at a major crossroads of trade and migration, offers an ideal setting for exploring population genetics. This study aimed to develop a Y-STR ... -
The role of PTP1B in cardiometabolic disorders and endothelial dysfunction
( Taylor and Francis Ltd. , 2025 , Article Review)Cardiovascular diseases (CVD) are a global health concern that accounts for a large share of annual mortality. Endothelial dysfunction is the main underlying factor that eventually leads to cardiovascular events. Recent ... -
Exploring TGF-β Signaling in Cancer Progression: Prospects and Therapeutic Strategies
( Dove Medical Press Ltd , 2025 , Article Review)Cancer persists as a ubiquitous global challenge despite the remarkable advances. It is caused by uncontrolled cell growth and metastasis. The Transforming Growth Factor-beta (TGF-β) signaling pathway is considered a primary ...
