Biomedical Sciences: Recent submissions
Now showing items 41-60 of 738
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Integrated structural proteomics and machine learning-guided mapping of a highly protective precision vaccine against mycoplasma pulmonis
( Elsevier , 2024 , Article)Mycoplasma pulmonis (M. pulmonis) is an emerging respiratory infection commonly linked to prostate cancer, and it is classified under the group of mycoplasmas. Improved management of mycoplasma infections is essential due ... -
Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications
( MDPI , 2024 , Article Review)The aim of this study is to provide an overview of the current state-of-the-art in the fabrication of bioceramic scaffolds for bone tissue engineering, with an emphasis on the use of three-dimensional (3D) technologies ... -
Inhibition of cytochrome P450 epoxygenase promotes endothelium-to-mesenchymal transition and exacerbates doxorubicin-induced cardiovascular toxicity
( Springer Nature , 2024 , Article)Background: Doxorubicin (DOX) is a potent chemotherapy widely used in treating various neoplastic diseases. However, the clinical use of DOX is limited due to its potential toxic effect on the cardiovascular system. Thus, ... -
Proteomic Analysis of Prehypertensive and Hypertensive Patients: Exploring the Role of the Actin Cytoskeleton
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Hypertension is a pervasive and widespread health condition that poses a significant risk factor for cardiovascular disease, which includes conditions such as heart attack, stroke, and heart failure. Despite its widespread ... -
Genetic polymorphisms and their association with neurobiological and psychological factors in anorexia nervosa: a systematic review
( Frontiers Media SA , 2024 , Article Review)Background and aims: Anorexia nervosa (AN) is a complex neuropsychiatric disorder. This systematic review synthesizes evidence from diverse studies to assess and investigate the association between gene polymorphisms and ... -
Facilitating inclusive education: Assessing faculty awareness and attitudes towards students with special educational needs at Qatar university
( Elsevier , 2024 , Article)Introduction: An increasing number of students with special educational needs (SEN) are attending higher education institutions. Faculty members are key players in the implementation of inclusive policies, the success of ... -
Reverse Zoonotic Transmission of SARS-CoV-2 and Monkeypox Virus: A Comprehensive Review
( Springer Nature , 2024 , Article Review)Reverse zoonosis reveals the process of transmission of a pathogen through the human-animal interface and the spillback of the zoonotic pathogen. In this article, we methodically demonstrate various aspects of reverse ... -
Material modeling and recent findings in transcatheter aortic valve implantation simulations
( Elsevier , 2024 , Article Review)Background and objective: Transcatheter aortic valve implantation (TAVI) has significantly transformed the management of aortic valve (AV) diseases, presenting a minimally invasive option compared to traditional surgical ... -
Question 5: Magnesium Sulphate for Acute Asthma in children
( W.B. Saunders Ltd , 2020 , Other)Most children who present to the emergency department with acute asthma, respond well to inhaled β2-agonists (spacer or nebuliser), oxygen (if required) and systemic steroids. Guidelines across the world agree on this ... -
Identification of potential natural inhibitors of the receptor-binding domain of the SARS-CoV-2 spike protein using a computational docking approach
( HBKU Press , 2021 , Article)Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin CoV to reach the pandemic stage, to which neither an effective vaccine nor a specific therapy is available. The ... -
Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar's experience
( Edinburgh University Global Health Society , 2022 , Article)Background The effective reproduction number, Rt, is a tool to track and understand pandemic dynamics. This investigation of Rt estimations was conducted to guide the national COVID-19 response in Qatar, from the onset of ... -
Smoking induced salivary microbiome dysbiosis and is correlated with lipid biomarkers
( Springer Nature , 2024 , Article)Background: The oral microbiome plays an essential role in maintaining oral homeostasis and health; smoking significantly affects it, leading to microbial dysbiosis. The study aims to investigate changes in the oral ... -
Medicinal properties of Qatari wetland plants: A review
( AkiNik Publications , 2024 , Article)For over 60,000 years, human dependence on herbal remedies has been a cornerstone of traditional medicine. However, recent times have witnessed escalating concerns about the sustainability of these practices, especially ... -
Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach
( MDPI , 2024 , Article Review)Immunotherapy is now established as a potent therapeutic paradigm engendering antitumor immune response against a wide range of malignancies and other diseases by modulating the immune system either through the stimulation ... -
ChatGPT’s scorecard after the performance in a series of tests conducted at the multi-country level: A pattern of responses of generative artificial intelligence or large language models
( Elsevier , 2024 , Article)Recently, researchers have shown concern about the ChatGPT-derived answers. Here, we conducted a series of tests using ChatGPT by individual researcher at multi-country level to understand the pattern of its answer accuracy, ... -
Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background: Resting electrocardiogram (ECG) is a valuable non-invasive diagnostic tool used in clinical medicine to assess the electrical activity of the heart while the patient is resting. Abnormalities in ECG may be ... -
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
( Nature Research , 2021 , Article)Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ... -
Development of Recombinant PLC-Zeta Protein as a Therapeutic Intervention for the Clinical Treatment of Oocyte Activation Failure
( MDPI , 2024 , Article)The sperm-specific phospholipase C zeta (PLCζ) protein is widely considered as the predominant physiological stimulus for initiating the Ca2+ release responsible for oocyte activation during mammalian fertilization. The ... -
Genetic Susceptibility to Arrhythmia Phenotypes in a Middle Eastern Cohort of 14,259 Whole-Genome Sequenced Individuals
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background: The current study explores the genetic underpinnings of cardiac arrhythmia phenotypes within Middle Eastern populations, which are under-represented in genomic medicine research. Methods: Whole-genome sequencing ... -
Effectiveness of two and three doses of COVID-19 mRNA vaccines against infection, symptoms, and severity in the pre-omicron era: A time-dependent gradient
( Elsevier , 2024 , Article)BackgroundVaccines were developed and deployed to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to characterize patterns in the protection provided by the BNT162b2 and ...
