Biomedical Sciences: Recent submissions
Now showing items 121-140 of 763
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Exploring the natural products chemical space to abrogate the F3L-dsRNA interface of monkeypox virus to enhance the immune responses using molecular screening and free energy calculations
( Frontiers Media SA , 2023 , Article)Amid the ongoing monkeypox outbreak, there is an urgent need for the rapid development of effective therapeutic interventions capable of countering the immune evasion mechanisms employed by the monkeypox virus (MPXV). The ... -
Uncommon presentation of complicated internal hernia through the appendices epiploicae ring of adhesion: a clinical case study
( Frontiers Media , 2024 , Article)Background: Internal hernias are infrequent, yet serious, medical conditions with potentially severe consequences. An internal hernia resulting from an Appendices epiploicae (AE) ring is an especially rare cause, with a ... -
Breaking Barriers: The Promise and Challenges of Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with pronounced immunogenicity, exhibiting rapid proliferation and immune cell infiltration into the tumor microenvironment. TNBC’s heterogeneity poses ... -
An optimized CT-dense agent perfusion and micro-CT imaging protocol for chick embryo developmental stages.
( BMC , 2024 , Article)Compared to classical techniques of morphological analysis, micro-CT (μ-CT) has become an effective approach allowing rapid screening of morphological changes. In the present work, we aimed to provide an optimized micro-CT ... -
Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties
( IOP Publishing , 2024 , Article)Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being ... -
In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model
( Elsevier , 2024 , Article)Heart failure (HF) is a multifactorial, heterogeneous systemic disease that is considered one of the leading causes of death and morbidity worldwide. It is well-known that endothelial dysfunction (ED) plays an important ... -
The Association between Lifestyle Factors and COVID-19: Findings from Qatar Biobank.
( MDPI , 2024 , Article)Coronavirus Disease 2019 (COVID-19) manifestations range from mild to severe life-threatening symptoms, including death. COVID-19 susceptibility has been associated with various factors, but studies in Qatar are limited. ... -
Biological and biomedical functions of Penta-O-galloyl-D-glucose and its derivatives
( Springer Nature , 2014 , Article Review)Penta-O-galloyl-D-glucose (PGG) is a simple hydrolysable tannin in plants. PGG exists in two anomeric forms, α-PGG and β-PGG. While β-PGG can be found in a wide variety of plants, α-PGG is rather rare in nature. Numerous ... -
In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer
( International Institute of Anticancer Research , 2014 , Article)Previously, our laboratory reported on novel quinuclidinone derivatives that cause cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299). The current study aims to investigate the effect of ... -
Glucose- and triglyceride-lowering dietary penta-O-galloyl-α-D-glucose reduces expression of PPARγ and C/EBPα, induces p21-Mediated G1 phase cell cycle arrest, and inhibits adipogenesis in 3T3-L1 preadipocytes
( Thieme , 2015 , Article)Plant polyphenols, such as hydrolysable tannins, are present in the human diet and known to exhibit anti-diabetic and anti-obesity activity. We previously reported that the representative hydrolysable tannin compound ... -
Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study
( Frontiers Media SA , 2024 , Article)Background: Metformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim ... -
Novel thiosemicarbazides induced apoptosis in human MCF-7 breast cancer cells via JNK signaling
( Taylor & Francis , 2015 , Article)In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound ... -
The effect of novel nitrogen-based chalcone analogs on colorectal cancer cells: Insight into the molecular pathways
( Elsevier , 2024 , Article)In colorectal cancer (CRC), aberrations in KRAS are associated with aggressive tumorigenesis and an overall low survival rate because of chemoresistance and adverse effects. Ergo, complementary, and integrative medicines ... -
Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance (Molecular Cancer, (2020), 19, 1, (57), 10.1186/s12943-020-01175-9)
( BMC , 2020 , Article)Following the publication of the original article [1], authors have noticed that one of the authors, Syed Shadab Raza, was missing in the Authors’ Contributions section. Please see below updated section. -
Forging the Path to Precision Medicine in Qatar: A Public Health Perspective on Pharmacogenomics Initiatives
( Frontiers Media , 2024 , Article Review)Pharmacogenomics (PGx) is an important component of precision medicine that promises tailored treatment approaches based on an individual’s genetic information. Exploring the initiatives in research that help to integrate ... -
The role of genetic and epigenetic GNAS alterations in the development of early-onset obesity
( Elsevier , 2023 , Article)BackgroundGNAS (guanine nucleotide-binding protein, alpha stimulating) is an imprinted gene that encodes Gsα, the α subunit of the heterotrimeric stimulatory G protein. This subunit mediates the signalling of a diverse ... -
Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
( Taylor and Francis Ltd. , 2024 , Article)In this study, we investigated the effects of an ethanolic extract of Mangifera indica L. kernel on the viability and proliferation of human lung cancer cells. We utilized MTT and BrdU cell proliferation assays, morphological ... -
Congenital absence of appendix: a rare condition that could result in severe complications-a review of literature
( Oxford University Press , 2023 , Article)Acute appendicitis is the most frequent cause of abdominal pain and acute emergency surgeries, with a mortality risk of 6-7% at its onset. Since atypical deviations in these structures are rare, they can lead to diagnosis ... -
Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions
( Springer , 2024 , Article)Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by altered brain connectivity and function. In this study, we employed advanced bioinformatics and explainable AI to analyze gene ... -
Rational design of a multivalent vaccine targeting arthropod-borne viruses using reverse vaccinology strategies
( Elsevier , 2024 , Article)Viruses transmitted by arthropods, such as Dengue, Zika, and Chikungunya, represent substantial worldwide health threats, particularly in countries like India. The lack of approved vaccines and effective antiviral therapies ...
