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AuthorUllah, Asad
AuthorMamun, Abdulla Al
AuthorZaidi, Midhat Batool
AuthorRoome, Talat
AuthorHasan, Anwarul
Available date2023-10-08T08:41:45Z
Publication Date2023
Publication NameBiomedicine and Pharmacotherapy
ResourceScopus
ISSN7533322
URIhttp://dx.doi.org/10.1016/j.biopha.2023.115156
URIhttp://hdl.handle.net/10576/48310
AbstractImpaired wound healing is a major healthcare problem in patients with diabetes often resulting in gangrene, microbial infection and amputation of affected limb. The delay or absence in healing process arises from several abnormalities, among them chronic hypoxia is a major concern due to its associated issues such as lack of collagen deposition, epithelization, fibroplasia, angiogenesis, and resistance to infections at the wound site. To address hypoxia, delivery of oxygen at the wound site through oxygen releasing agents have been proven to be effective therapeutics. Several oxygen releasing nanoparticles such as Sodium Percarbonate (SPC), Calcium Peroxide (CPO), Hydrogen Peroxide, Magnesium Peroxide (MPO) have been investigated in wound healing application. However, the uncontrolled/burst release of these nanotherapeutic agents and its accompanied cytotoxicity pose a barrier in expediting the healing process. In this study, a Chitosan-Polyvinyl alcohol (CS-PVA) based hydrogel containing oxygen releasing nanoparticle, calcium peroxide (CPO) was constructed to provide a slow and sustained delivery of oxygen for at least 5 days. In-vitro cell culture studies with this material using fibroblast and endothelial cell line exhibited improved biocompatibility, cell viability and enhanced proliferation in comparison with the control group. Additionally, cell migration study using scratch assay method showed superior cell migration ability of our proposed materials. Furthermore, In vivo study using diabetic rat model showed accelerated wound closure rate compared to untreated control wounds.
SponsorThis article was made possible by the NPRP12S-0310-190276 grant funded by the Qatar National Research Fund (a part of the Qatar Foundation). Funding for Open Access publication fee was provided by the Qatar National Library. We also acknowledge the support provided by the Central Laboratories Unit (CLU), Qatar University, Qatar.
Languageen
PublisherElsevier
SubjectChronic hypoxia
Diabetic wound healing
Oxygen releasing materials
TitleA calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing
TypeArticle
Volume Number165
dc.accessType Open Access


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