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المؤلفMir, Fayaz Ahmad
المؤلفUllah, Ehsan
المؤلفMall, Raghvendra
المؤلفIskandarani, Ahmad
المؤلفSamra, Tareq A.
المؤلفCyprian, Farhan
المؤلفParray, Aijaz
المؤلفAlkasem, Meis
المؤلفAbdalhakam, Ibrahem
المؤلفFarooq, Faisal
المؤلفAbou-Samra, Abdul Badi
تاريخ الإتاحة2023-10-11T10:09:30Z
تاريخ النشر2022-08-29
اسم المنشورInternational Journal of Molecular Sciences
المعرّفhttp://dx.doi.org/10.3390/ijms23179821
الاقتباسMir, F. A., Ullah, E., Mall, R., Iskandarani, A., Samra, T. A., Cyprian, F., ... & Abou-Samra, A. B. (2022). Dysregulated metabolic pathways in subjects with obesity and metabolic syndrome. International Journal of Molecular Sciences, 23(17), 9821.
الرقم المعياري الدولي للكتاب1661-6596
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137585363&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/48448
الملخصBackground: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic syndrome in Arabic subjects with obesity. Methods: We analyzed a dataset of 39 subjects with obesity only (OBO, n = 18) age-matched to subjects with obesity and metabolic syndrome (OBM, n = 21). We measured 1069 serum metabolites and correlated them to clinical features. Results: A total of 83 metabolites, mostly lipids, were significantly different (p < 0.05) between the two groups. Among lipids, 22 sphingomyelins were decreased in OBM compared to OBO. Among non-lipids, quinolinate, kynurenine, and tryptophan were also decreased in OBM compared to OBO. Sphingomyelin is negatively correlated with glucose, HbA1C, insulin, and triglycerides but positively correlated with HDL, LDL, and cholesterol. Differentially enriched pathways include lysine degradation, amino sugar and nucleotide sugar metabolism, arginine and proline metabolism, fructose and mannose metabolism, and galactose metabolism. Conclusions: Metabolites and pathways associated with chronic inflammation are differentially expressed in subjects with obesity and metabolic syndrome compared to subjects with obesity but without the clinical features of metabolic syndrome.
راعي المشروعThis publication was made possible by MRC grant, MRC# 16245/16, from the Medical Research Centre, Hamad Medical Corporation, Doha, Qatar. Qatar National Library funded the publication of this article.
اللغةen
الناشرMultidisciplinary Digital Publishing Institute (MDPI)
الموضوعinflammation
metabolic syndrome
metabolomics
obesity
sphingomyelins
العنوانDysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome
النوعArticle
رقم العدد17
رقم المجلد23
ESSN1422-0067
dc.accessType Open Access


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