Show simple item record

AuthorMir, Fayaz Ahmad
AuthorUllah, Ehsan
AuthorMall, Raghvendra
AuthorIskandarani, Ahmad
AuthorSamra, Tareq A.
AuthorCyprian, Farhan
AuthorParray, Aijaz
AuthorAlkasem, Meis
AuthorAbdalhakam, Ibrahem
AuthorFarooq, Faisal
AuthorAbou-Samra, Abdul Badi
Available date2023-10-11T10:09:30Z
Publication Date2022-08-29
Publication NameInternational Journal of Molecular Sciences
Identifierhttp://dx.doi.org/10.3390/ijms23179821
CitationMir, F. A., Ullah, E., Mall, R., Iskandarani, A., Samra, T. A., Cyprian, F., ... & Abou-Samra, A. B. (2022). Dysregulated metabolic pathways in subjects with obesity and metabolic syndrome. International Journal of Molecular Sciences, 23(17), 9821.
ISSN1661-6596
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137585363&origin=inward
URIhttp://hdl.handle.net/10576/48448
AbstractBackground: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic syndrome in Arabic subjects with obesity. Methods: We analyzed a dataset of 39 subjects with obesity only (OBO, n = 18) age-matched to subjects with obesity and metabolic syndrome (OBM, n = 21). We measured 1069 serum metabolites and correlated them to clinical features. Results: A total of 83 metabolites, mostly lipids, were significantly different (p < 0.05) between the two groups. Among lipids, 22 sphingomyelins were decreased in OBM compared to OBO. Among non-lipids, quinolinate, kynurenine, and tryptophan were also decreased in OBM compared to OBO. Sphingomyelin is negatively correlated with glucose, HbA1C, insulin, and triglycerides but positively correlated with HDL, LDL, and cholesterol. Differentially enriched pathways include lysine degradation, amino sugar and nucleotide sugar metabolism, arginine and proline metabolism, fructose and mannose metabolism, and galactose metabolism. Conclusions: Metabolites and pathways associated with chronic inflammation are differentially expressed in subjects with obesity and metabolic syndrome compared to subjects with obesity but without the clinical features of metabolic syndrome.
SponsorThis publication was made possible by MRC grant, MRC# 16245/16, from the Medical Research Centre, Hamad Medical Corporation, Doha, Qatar. Qatar National Library funded the publication of this article.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjectinflammation
metabolic syndrome
metabolomics
obesity
sphingomyelins
TitleDysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome
TypeArticle
Issue Number17
Volume Number23
ESSN1422-0067
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record