Identification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens
Author | Sotgia, Salvatore |
Author | Mangoni, Arduino A. |
Author | Forteschi, Mauro |
Author | Murphy, Rhys B. |
Author | Elliot, David |
Author | Sotgiu, Elisabetta |
Author | Pintus, Gianfranco |
Author | Carru, Ciriaco |
Author | Zinellu, Angelo |
Available date | 2016-10-12T10:27:20Z |
Publication Date | 2016-09-28 |
Publication Name | Molecules |
Identifier | http://dx.doi.org/10.3390/molecules21101298 |
Citation | Sotgia, S.; Mangoni, A.A.; Forteschi, M.; Murphy, R.B.; Elliot, D.; Sotgiu, E.; Pintus, G.; Carru, C.; Zinellu, A. Identification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens. Molecules 2016, 21, 1298. |
Abstract | A capillary electrophoresis coupled to tandem mass spectrometry (CE–MS/MS) has been used to make a qualitative determination of hercynine—the main precursor of l-ergothioneine biosynthesis—in some key human biological specimens, such as urine, whole blood, plasma, and saliva. From semiquantitative analysis results, the highest concentrations of hercynine were detected in saliva and whole blood, whereas much lower concentrations were measured in urine and plasma. Whole blood was the biological matrix with the highest concentration of l-ergothioneine followed by plasma, saliva, and urine. The antioxidant effects attributed to l-ergothioneine, along with its peculiar antioxidant mechanism, offer a possible explanation for the presence of the hercynine, as well as its concentration, in the considered biological matrices. |
Sponsor | "Fondazione Banco di Sardegna”, Sassari, Italy, and by the “Ministero dell’Università e della Ricerca”, Italy |
Language | en |
Publisher | MDPI AG |
Subject | aminothione capillary electrophoresis mass spectrometry quaternary ammonium dismutation |
Type | Article |
Issue Number | 10 |
Volume Number | 21 |
ESSN | 1420-3049 |
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Biomedical Sciences [692 items ]