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AuthorAl-Omari, Mothana K.
AuthorElaarag, Mai
AuthorAl-Zoubi, Raed M.
AuthorAl-Qudimat, Ahmad R.
AuthorZarour, Ayman A.
AuthorAl-Hurani, Enas A.
AuthorFares, Zainab E.
AuthorAlkharraz, Leena M.
AuthorShkoor, Mohanad
AuthorBani-Yaseen, Abdulilah D.
AuthorAboumarzouk, Omar M.
AuthorYassin, Aksam
AuthorAl-Ansari, Abdulla A.
Available date2023-11-05T06:14:30Z
Publication Date2023
Publication NameJournal of Enzyme Inhibition and Medicinal Chemistry
ResourceScopus
ISSN14756366
URIhttp://dx.doi.org/10.1080/14756366.2023.2220084
URIhttp://hdl.handle.net/10576/49017
AbstractBoronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can mimic certain types of antibodies to fight infections. They have been designed and developed into drugs, and this approach has emerged in the last 20 years. Five boronic acid drugs have been approved by the FDA and Health Canada, two of which are used to treat cancer, specifically multiple myeloma. The purpose of this review is to investigate boronic acid/ester derivatives as potential pharmaceutical agents as well as the mechanism of action. It will concentrate on six types of cancer: multiple myeloma, prostate cancer, breast cancer, lung cancer, cervical cancer, and colon cancer. Some newly developed boron-containing compounds have already demonstrated highly promising activities, but further investigation is required before final conclusions can be drawn.
SponsorThe publication of this article was funded by the Qatar National Library. Open Access funding provided by the Qatar National Library.
Languageen
PublisherTaylor and Francis Ltd.
SubjectBoronic acid
cancer disease
drug
enzyme inhibitor
mechanism
TitleOrganoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
TypeArticle Review
Issue Number1
Volume Number38
dc.accessType Open Access


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