Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar
Author | Fernandes, Queenie |
Author | Gupta, Ishita |
Author | Murshed, Khaled |
Author | Samra, Hayan Abo |
Author | Al-Thawadi, Hamda |
Author | Vranic, Semir |
Author | Petkar, Mahir |
Author | Babu, Giridhara Rathnaiah |
Author | Al Moustafa, Ala-Eddin |
Available date | 2023-11-05T06:14:31Z |
Publication Date | 2023 |
Publication Name | Human Vaccines and Immunotherapeutics |
Resource | Scopus |
ISSN | 21645515 |
Abstract | High-risk Human Papillomaviruses (HPVs) and Epstein-Barr virus (EBV) are present and involved in several types of human carcinomas, including cervical and, head and neck cancers. Nevertheless, their presence and association in the pathogenesis of colorectal cancer is still nascent. The current study explored the association between the high-risk HPVs and EBV and tumor phenotype in colorectal cancers (CRCs) in the Qatari population. We found that high-risk HPVs and EBV are present in 69/100 and 21/100 cases, respectively. Additionally, 17% of the cases showed a copresence of high-risk HPVs and EBV, with a significant correlation only between the HPV45 subtype and EBV (p =.004). While the copresence did not significantly associate with clinicopathological characteristics, we identified that coinfection with more than two subtypes of HPV is a strong predictor of advanced stage CRC, and the confounding effect of the copresence of EBV in such cases strengthens this association. Our results indicate that high-risk HPVs and EBV can co-present in human CRCs in the Qatari population where they could plausibly play a specific role in human colorectal carcinogenesis. However, future studies are essential to confirm their copresence and synergistic role in developing CRCs. |
Sponsor | Our lab is supported by grants from Qatar University: QUCP-CMED-2021-1. We would like to thank A. Kassab for her critical reading of the manuscript. Special Thanks to Dr. Said Dermime for his scientific advice and support. Open Access funding provided by the Qatar National Library. |
Language | en |
Publisher | Taylor and Francis Ltd. |
Subject | Colorectal cancer Epstein-Barr virus human papillomavirus oncoviral coinfection oncovirus Qatar |
Type | Article |
Issue Number | 2 |
Volume Number | 19 |
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