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المؤلفAlmaghrbi, Heba
المؤلفAl-Shafai, Mashael
المؤلفAl-Asmakh, Maha
المؤلفBawadi, Hiba
تاريخ الإتاحة2023-11-13T08:00:14Z
تاريخ النشر2023-09-01
اسم المنشورNutrients
المعرّفhttp://dx.doi.org/10.3390/nu15184040
الاقتباسAlmaghrbi, H., Al-Shafai, M., Al-Asmakh, M., & Bawadi, H. (2023). Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review. Nutrients, 15(18), 4040.‏
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85172193730&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/49213
الملخصBackground and Aims: The genetic risk score (GRS) is an important tool for estimating the total genetic contribution or susceptibility to a certain outcome of interest in an individual, taking into account their genetic risk alleles. This study aims to systematically review the association between the GRS of low vitamin D with different noncommunicable diseases/markers. Methods: The article was first registered in PROSPERO CRD42023406929. PubMed and Embase were searched from the time of inception until March 2023 to capture all the literature related to the vitamin D genetic risk score (vD-GRS) in association with noncommunicable diseases. This was performed using comprehensive search terms including “Genetic Risk Score” OR “Genetics risk assessment” OR “Genome-wide risk score” AND “Vitamin D” OR 25(HO)D OR “25-hydroxyvitamin D”. Results: Eleven eligible studies were included in this study. Three studies reported a significant association between vD-GRS and metabolic parameters, including body fat percentage, body mass index, glycated hemoglobin, and fasting blood glucose. Moreover, colorectal cancer overall mortality and the risk of developing arterial fibrillation were also found to be associated with genetically deprived vitamin D levels. Conclusions: This systematic review highlights the genetic contribution of low-vitamin-D-risk single nucleotides polymorphisms (SNPs) as an accumulative factor associated with different non-communicable diseases/markers, including cancer mortality and the risk of developing obesity, type 2 diabetes, and cardiovascular diseases such as arterial fibrillation.
اللغةen
الناشرMDPI
الموضوعgenetic predisposition
genetic risk score
GWAS
noncommunicable diseases
single nucleotide polymorphisms
vitamin D
العنوانAssociation of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review
النوعArticle
رقم العدد18
رقم المجلد15
dc.accessType Open Access


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