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AuthorAl-Shami, Khayry
AuthorAwadi, Sajeda
AuthorKhamees, Almu'atasim
AuthorAlsheikh, Ahmad Malek
AuthorAl-Sharif, Sumaiya
AuthorAla’ Bereshy, Raneem
AuthorAl-Eitan, Sharaf F.
AuthorBanikhaled, Sajedah H.
AuthorAl-Qudimat, Ahmad R.
AuthorAl-Zoubi, Raed M.
AuthorAl Zoubi, Mazhar Salim
Available date2023-11-15T08:04:18Z
Publication Date2023-09-01
Publication NameHeliyon
Identifierhttp://dx.doi.org/10.1016/j.heliyon.2023.e20224
CitationAl-Shami, K., Awadi, S., Alsheikh, A. M., Al-Sharif, S., Ala’Bereshy, R., Al-Eitan, S. F., ... & Al Zoubi, M. S. (2023). Estrogens and the risk of breast cancer: A narrative review of literature. Heliyon.‏
ISSN24058440
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85171832026&origin=inward
URIhttp://hdl.handle.net/10576/49335
AbstractIn female mammals, the development and regulation of the reproductive system and non-reproductive system are significantly influenced by estrogens (oestrogens). In addition, lipid metabolism is another physiological role of estrogens. Estrogens act through different types of receptors to introduce signals to the target cell by affecting many estrogen response elements. Breast cancer is considered mostly a hormone-dependent disease. Approximately 70% of breast cancers express progesterone receptors and/or estrogen receptors, and they are a good marker for cancer prognosis. This review will discuss estrogen metabolism and the interaction of estrogen metabolites with breast cancer. The carcinogenic role of estrogen is discussed in light of both conventional and atypical cancers susceptible to hormones, such as prostate, endometrial, and lung cancer, as we examine how estrogen contributes to the formation and activation of breast cancer. In addition, this review will discuss other factors that can be associated with estrogen-driven breast cancer.
Languageen
PublisherElsevier Ltd
SubjectBreast cancer
ER
Estrogen
Oestrogen
Risk
TitleEstrogens and the risk of breast cancer: A narrative review of literature
TypeArticle
Issue Number9
Volume Number9
dc.accessType Open Access


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