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AuthorTluli, Omar
AuthorAl-Maadhadi, Mazyona
AuthorAl-Khulaifi, Aisha Abdulla
AuthorAkomolafe, Aishat F.
AuthorAl-Kuwari, Shaikha Y.
AuthorAl-Khayarin, Roudha
AuthorMaccalli, Cristina
AuthorPedersen, Shona
Available date2023-11-15T11:06:05Z
Publication Date2023-09-01
Publication NameCancers
Identifierhttp://dx.doi.org/10.3390/cancers15174213
CitationTluli, O., Al-Maadhadi, M., Al-Khulaifi, A. A., Akomolafe, A. F., Al-Kuwari, S. Y., Al-Khayarin, R., ... & Pedersen, S. (2023). Exploring the Role of microRNAs in Glioma Progression, Prognosis, and Therapeutic Strategies. Cancers, 15(17), 4213.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85170249096&origin=inward
URIhttp://hdl.handle.net/10576/49339
AbstractGliomas, which arise from glial cells in the brain, remain a significant challenge due to their location and resistance to traditional treatments. Despite research efforts and advancements in healthcare, the incidence of gliomas has risen dramatically over the past two decades. The dysregulation of microRNAs (miRNAs) has prompted the creation of therapeutic agents that specially target them. However, it has been reported that they are involved in complex signaling pathways that contribute to the loss of expression of tumor suppressor genes and the upregulation of the expression of oncogenes. In addition, numerous miRNAs promote the development, progression, and recurrence of gliomas by targeting crucial proteins and enzymes involved in metabolic pathways such as glycolysis and oxidative phosphorylation. However, the complex interplay among these pathways along with other obstacles hinders the ability to apply miRNA targeting in clinical practice. This highlights the importance of identifying specific miRNAs to be targeted for therapy and having a complete understanding of the diverse pathways they are involved in. Therefore, the aim of this review is to provide an overview of the role of miRNAs in the progression and prognosis of gliomas, emphasizing the different pathways involved and identifying potential therapeutic targets.
Languageen
PublisherMDPI
Subjectcancer stem cells
glioma
microRNA
prognosis
targeted therapy
TitleExploring the Role of microRNAs in Glioma Progression, Prognosis, and Therapeutic Strategies
TypeArticle
Issue Number17
Volume Number15
dc.accessType Open Access


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