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AuthorAbdelkader, Nada Nabil
AuthorAwaisu, Ahmed
AuthorElewa, Hazem
AuthorEl Hajj, Maguy Saffouh
Available date2023-11-19T05:45:32Z
Publication Date2023
Publication NameExploratory Research in Clinical and Social Pharmacy
ResourceScopus
ISSN26672766
URIhttp://dx.doi.org/10.1016/j.rcsop.2023.100315
URIhttp://hdl.handle.net/10576/49411
AbstractBackground: Hypertension has affected over 1.13 billion people worldwide in 2015 and it's one of the most preventable risk-factors for morbidity and mortality. Antihypertensives significantly reduce cardiovascular risks. Several studies on antihypertensives' prescribing patterns were conducted worldwide, and guidelines were developed on hypertension management. However, no systematic reviews were conducted globally to synthesize the evidence from these studies. This review aims to evaluate antihypertensives' prescription patterns, and adherence to international guidelines for hypertension management worldwide. Methods: Full-text antihypertensives' prescribing patterns evaluation studies were included. Reviews, commentaries, guidelines, and editorials were excluded. Various databases were searched including PubMed, Embase, and others. Studies were limited to English only and to articles published from (01/01/2010) to (20/03/2020). Crowe Critical Appraisal Tool (CCAT) was used for quality assessment. Results: The most commonly prescribed antihypertensives as monotherapy in adult patients with no comorbidities were ACEIs/ARBs (Angiotensin converting enzyme inhibitors/Angiotensin receptor blockers), followed by CCBs (Calcium channel blockers), and BBs (Beta Blockers). Most commonly prescribed dual combinations were thiazide diuretics+ACEIs/ARBs, BBs + CCBs and CCBs+ACEIs/ARBs. Among diabetic patients, the most common agents were ACEIs/ARBs. Among patients with heart diseases, CCBs were prescribed frequently. While patients with kidney diseases, CCBs and ARBs were most prescribed. Of the 40 studies included in the review, only four studies directly assessed the prescribing patterns of antihypertensives in adherence to clinical practice guidelines. And only two studies confirmed adherence to guidelines. Furthermore, the quality of the majority of studies was moderate (50%), while 25% of articles were reported as either high or low quality. Conclusion: This review revealed that there are areas for improvement for prescribing practices of antihypertensives in concordance with the latest evidence and with clinical practice guidelines.
SponsorThis work was supported by a student grant (grant number QUST-2-CPH-2020-20 ) from Qatar University Office of Research and Graduate Studies . Its contents are solely the responsibility of the authors and do not necessarily represent the official views of Qatar University.
Languageen
PublisherElsevier
SubjectGuidelines
Hypertension
Prescribing patterns
Review
TitlePrescribing patterns of antihypertensive medications: A systematic review of literature between 2010 and 2020
TypeArticle Review
Volume Number11
dc.accessType Open Access


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