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المؤلفSekaran, Karthik
المؤلفVarghese, Rinku Polachirakkal
المؤلفDoss C., George Priya
المؤلفAlsamman, Alsamman M.
المؤلفZayed, Hatem
المؤلفEl Allali, Achraf
تاريخ الإتاحة2023-11-19T05:45:35Z
تاريخ النشر2023
اسم المنشورPloS one
المصدرScopus
الرقم المعياري الدولي للكتاب19326203
معرّف المصادر الموحدhttp://dx.doi.org/10.1371/journal.pone.0289891
معرّف المصادر الموحدhttp://hdl.handle.net/10576/49441
الملخصNew evidence strongly discloses the pathogenesis of host-associated microbiomes in respiratory diseases. The microbiome dysbiosis modulates the lung's behavior and deteriorates the respiratory system's effective functioning. Several exogenous and environmental factors influence the development of asthma and chronic lung disease. The relationship between asthma and microbes is reasonably understood and yet to be investigated for more substantiation. The comorbidities such as SARS-CoV-2 further exacerbate the health condition of the asthma-affected individuals. This study examines the raw 16S rRNA sequencing data collected from the saliva and nasopharyngeal regions of pre-existing asthma (23) and non-asthma patients (82) infected by SARS-CoV-2 acquired from the public database. The experiment is designed in a two-fold pattern, analyzing the associativity between the samples collected from the saliva and nasopharyngeal regions. Later, investigates the microbial pathogenesis, its role in exacerbations of respiratory disease, and deciphering the diagnostic biomarkers of the target condition. LEfSE analysis identified that Actinobacteriota and Pseudomonadota are enriched in the SARS-CoV-2-non-asthma group and SARS-CoV-2 asthma group of the salivary microbiome, respectively. Random forest algorithm is trained with amplicon sequence variants (ASVs) attained better classification accuracy, ROC scores on nasal (84% and 87%) and saliva datasets (93% and 97.5%). Rothia mucilaginosa is less abundant, and Corynebacterium tuberculostearicum showed higher abundance in the SARS-CoV-2 asthma group. The increase in Streptococcus at the genus level in the SARS-CoV-2-asthma group is evidence of discriminating the subgroups.
اللغةen
الناشرNLM (Medline)
الموضوعAirway
Oral microbiome profiling
SARS-CoV-2
infected asthma
non-asthma cases
A pulmonary microbial investigation
العنوانAirway and Oral microbiome profiling of SARS-CoV-2 infected asthma and non-asthma cases revealing alterations-A pulmonary microbial investigation
النوعArticle
الصفحاتe0289891
رقم العدد8
رقم المجلد18
dc.accessType Open Access


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