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AuthorAlmohammed, Eida Khalaf
AuthorHadi, Abdullah
AuthorAl-Asmakh, Maha
AuthorLazim, Hayder
Available date2023-11-19T05:45:36Z
Publication Date2023
Publication NamePLoS ONE
ResourceScopus
ISSN19326203
URIhttp://dx.doi.org/10.1371/journal.pone.0290844
URIhttp://hdl.handle.net/10576/49444
AbstractThe Y-chromosome has been widely used in forensic genetic applications and human population genetic studies due to its uniparental origins. A large database on the Qatari population was created for comparison with other databases from the Arabian Peninsula, the Middle East, and Africa. We provide a study of 23 Y-STR loci included in PowerPlex Y23 (Promega, USA) that were genotyped to produce haplotypes in 379 unrelated males from Qatar, a country at the crossroads of migration patterns. Overall, the most polymorphic locus provided by the Promega kit was DYS458, with a genetic diversity value of 0.85 and a haplotype diversity of 0.998924. Athey's Haplogroup Predictor tool was used to predict haplogroups from Y-STR haplotypes in the Qatari population. In a median-joining network, the haplogroup J1 predominance (49%) in Qatar generated a star-like expansion cluster. The graph of population Q-matrix was developed using Y-STR data from 38 Middle Eastern and 97 African populations (11,305 individuals), and it demonstrated a stronger sub-grouping of countries within each ethnic group and showed the effect of Arabs on the indigenous Berbers of North Africa. The estimated migration rate between the Qatari and other Arabian populations was inferred using Bayesian coalescence theory in the Migrate-n program. According to the Gene Flow study, the main migration route was from Yemen to Kuwait through Qatar. Our research, using the PowerPlex Y23 database, shows the importance of gene diversity, as well as regional and social structuring, in determining the utility of demographic and forensic databases.
SponsorFunding: EA, The funding was provided by Ministry of Interior of Qatar (Ref: H.R.D/S.S/D-1/1126). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Languageen
PublisherPublic Library of Science
Subjectgenetic structure
gene flow
Y chromosome
The Qatari population's
TitleThe Qatari population's genetic structure and gene flow as revealed by the Y chromosome
TypeArticle
Issue Number9-Sep
Volume Number18
dc.accessType Open Access


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