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المؤلفAl-Asmakh, Maha
المؤلفHedin, Lars
تاريخ الإتاحة2016-11-06T07:12:49Z
تاريخ النشر2015-05-29
اسم المنشورTissue Barriers
المعرّفhttp://dx.doi.org/10.1080/21688370.2015.1039691
الاقتباسAl-Asmakh M, Hedin L. Microbiota and the control of blood-tissue barriers. Tissue Barriers. 2015;3(3):e1039691
الرقم المعياري الدولي للكتاب2168-8362
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4970
الملخصThe gastro-intestinal tract is an ecosystem containing trillions of commensal bacteria living in symbiosis with the host. These microbiota modulate a variety of our physiological processes, including production of vitamins, absorption of nutrients and development of the immune system. One of their major functions is to fortify the intestinal barrier, thereby helping to prevent pathogens and harmful substances from crossing into the general circulation. Recently, effects of these microbiota on other blood-tissue barriers have also been reported. Here, we review the evidence indicating that gut bacteria play a role in regulating the blood-brain and blood-testis barriers. The underlying mechanisms include control of the expression of tight junction proteins by fermentation products such as butyrate, which also influences the activity of histone deacetylase.
اللغةen
الناشرTaylor & Francis
الموضوعblood-brain barrier
blood-testis barrier
butyrate
intestinal barrier
microbiota
short chain fatty acids
tight junctions
العنوانMicrobiota and the control of blood-tissue barriers
النوعArticle
رقم العدد3
رقم المجلد3
ESSN2168-8370
dc.accessType Abstract Only


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