Cytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles
المؤلف | Al-Fahdawi, Mohamed Qasim |
المؤلف | Rasedee, Abdullah |
المؤلف | Al-Qubaisi, Mothanna Sadiq |
المؤلف | Alhassan, Fatah H. |
المؤلف | Rosli, Rozita |
المؤلف | El Zowalaty, Mohamed Ezzat |
المؤلف | Naadja, Seif-Eddine |
المؤلف | Webster, Thomas J. |
المؤلف | Taufiq-Yap, Yun Hin |
تاريخ الإتاحة | 2016-11-06T07:59:18Z |
تاريخ النشر | 2015-09-10 |
اسم المنشور | International Journal of Nanomedicine |
المعرّف | http://dx.doi.org/10.2147/IJN.S82586 |
الاقتباس | Al-Fahdawi MQ, Rasedee A, Al-Qubaisi MS, et al. Cytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles. International Journal of Nanomedicine. 2015;10:5739-5750. |
الرقم المعياري الدولي للكتاب | 1176-9114 |
الملخص | Iron–manganese-doped sulfated zirconia nanoparticles with both Lewis and Brønsted acidic sites were prepared by a hydrothermal impregnation method followed by calcination at 650°C for 5 hours, and their cytotoxicity properties against cancer cell lines were determined. The characterization was carried out using X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, Brauner–Emmett–Teller (BET) surface area measurements, X-ray fluorescence, X-ray photoelectron spectroscopy, zeta size potential, and transmission electron microscopy (TEM). The cytotoxicity of iron–manganese-doped sulfated zirconia nanoparticles was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays against three human cancer cell lines (breast cancer MDA-MB231 cells, colon carcinoma HT29 cells, and hepatocellular carcinoma HepG2 cells) and two normal human cell lines (normal hepatocyte Chang cells and normal human umbilical vein endothelial cells [HUVECs]). The results suggest for the first time that iron–manganese-doped sulfated zirconia nanoparticles are cytotoxic to MDA-MB231 and HepG2 cancer cells but have less toxicity to HT29 and normal cells at concentrations from 7.8 µg/mL to 500 µg/mL. The morphology of the treated cells was also studied, and the results supported those from the cytotoxicity study in that the nanoparticle-treated HepG2 and MDA-MB231 cells had more dramatic changes in cell morphology than the HT29 cells. In this manner, this study provides the first evidence that iron–manganese-doped sulfated zirconia nanoparticles should be further studied for a wide range of cancer applications without detrimental effects on healthy cell functions. |
اللغة | en |
الناشر | Dove Press |
الموضوع | HT29 cells Lewis and Brønsted acidic sites anticancer applications nanopartices transition metal oxide |
النوع | Article |
الصفحات | 5739-5750 |
رقم العدد | 1 |
رقم المجلد | 10 |
ESSN | 1178-2013 |
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