Sesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties
المؤلف | Amin F., Majdalawieh |
المؤلف | Ahari, Sogand H. |
المؤلف | Yousef, Sarah M. |
المؤلف | Nasrallah, Gheyath K. |
تاريخ الإتاحة | 2024-01-14T08:32:08Z |
تاريخ النشر | 2023-12-05 |
اسم المنشور | European Journal of Pharmacology |
المعرّف | http://dx.doi.org/10.1016/j.ejphar.2023.176163 |
الرقم المعياري الدولي للكتاب | 00142999 |
الملخص | Inflammation is associated with the development and progression of a plethora of diseases including joint, metabolic, neurological, hepatic, and renal disorders. Sesamol, derived from the seeds of Sesamum indicum L., has received considerable attention due to its well-documented multipotent phytotherapeutic effects, including its anti-inflammatory and immunomodulatory properties. However, to date, no comprehensive review has been established to highlight or summarize the anti-inflammatory and immunomodulatory properties of sesamol. Herein, we aim to address this gap in the literature by presenting a thorough review encapsulating evidence surrounding the range of inflammatory mediators and cytokines shown to be targeted by sesamol in modulating its anti-inflammatory actions against a range of inflammatory disorders. Additionally, evidence highlighting the role that sesamol has in modulating components of adaptive immunity including cellular immune responses and Th1/Th2 balance is underscored. Moreover, the molecular mechanisms and the signaling pathways underlying such effects are also highlighted. Findings indicate that this seemingly potent lignan mediates its anti-inflammatory actions, at least in part, via suppression of various pro-inflammatory cytokines like IL-1β and TNFα, and downregulation of a multitude of signaling pathways including NF-κB and MAPK. In conclusion, we anticipate that sesamol may be employed in future therapeutic regimens to aid in more effective drug development to alleviate immune-related and inflammatory conditions. |
اللغة | en |
الناشر | Elsevier |
الموضوع | Sesamol Lignans Th1/Th2 balance Inflammation Cytokines Anti-inflammatory agents |
النوع | Article |
رقم المجلد | 960 |
Open Access user License | http://creativecommons.org/licenses/by/4.0/ |
ESSN | 1879-0712 |
تحقق من خيارات الوصول
الملفات في هذه التسجيلة
هذه التسجيلة تظهر في المجموعات التالية
-
العلوم الحيوية الطبية [697 items ]