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AuthorAmin F., Majdalawieh
AuthorAhari, Sogand H.
AuthorYousef, Sarah M.
AuthorNasrallah, Gheyath K.
Available date2024-01-14T08:32:08Z
Publication Date2023-12-05
Publication NameEuropean Journal of Pharmacology
Identifierhttp://dx.doi.org/10.1016/j.ejphar.2023.176163
ISSN00142999
URIhttps://www.sciencedirect.com/science/article/pii/S0014299923006775
URIhttp://hdl.handle.net/10576/50709
AbstractInflammation is associated with the development and progression of a plethora of diseases including joint, metabolic, neurological, hepatic, and renal disorders. Sesamol, derived from the seeds of Sesamum indicum L., has received considerable attention due to its well-documented multipotent phytotherapeutic effects, including its anti-inflammatory and immunomodulatory properties. However, to date, no comprehensive review has been established to highlight or summarize the anti-inflammatory and immunomodulatory properties of sesamol. Herein, we aim to address this gap in the literature by presenting a thorough review encapsulating evidence surrounding the range of inflammatory mediators and cytokines shown to be targeted by sesamol in modulating its anti-inflammatory actions against a range of inflammatory disorders. Additionally, evidence highlighting the role that sesamol has in modulating components of adaptive immunity including cellular immune responses and Th1/Th2 balance is underscored. Moreover, the molecular mechanisms and the signaling pathways underlying such effects are also highlighted. Findings indicate that this seemingly potent lignan mediates its anti-inflammatory actions, at least in part, via suppression of various pro-inflammatory cytokines like IL-1β and TNFα, and downregulation of a multitude of signaling pathways including NF-κB and MAPK. In conclusion, we anticipate that sesamol may be employed in future therapeutic regimens to aid in more effective drug development to alleviate immune-related and inflammatory conditions.
Languageen
PublisherElsevier
SubjectSesamol
Lignans
Th1/Th2 balance
Inflammation
Cytokines
Anti-inflammatory agents
TitleSesamol: A lignan in sesame seeds with potent anti-inflammatory and immunomodulatory properties
TypeArticle
Volume Number960
Open Access user License http://creativecommons.org/licenses/by/4.0/
ESSN1879-0712
dc.accessType Full Text


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