Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac
المؤلف | Abdulilah Dawoud, Bani-Yaseen |
المؤلف | Al-Zoubi, Raed M. |
المؤلف | Shkoor, Mohanad |
تاريخ الإتاحة | 2024-01-22T06:15:05Z |
تاريخ النشر | 2023-11-30 |
اسم المنشور | Heliyon |
المعرّف | http://dx.doi.org/10.1016/j.heliyon.2023.e20767 |
الاقتباس | Bani-Yaseen, A. D., Al-Zoubi, R. M., & Shkoor, M. (2023). Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac. Heliyon, 9(11). |
الرقم المعياري الدولي للكتاب | 24058440 |
الملخص | The solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical reaction of DCF in a set of neat solvents demonstrates that the photoconversion reaction rate of DCF is not only medium polarity dependent but also hydrogen-bonding dependent. The solvent effects were qualitatively and quantitatively assessed employing various solvatochromic models, including multi-parameter linear regression analysis (MLRA). Interestingly, the MLRA results (R = 0.99) revealed that the photoconversion rate increases with increasing solvent polarizability (π*) and H-bond donor capability (α), whereas the rate decreases with increasing hydrogen-bond acceptor capability (β). However, predominant effect of the solvent acidity compared to basicity and polarizability was observed. A hypothesis rationalizing the effects of H-bonding and medium polarity on DCF photoconversion reaction is presented and discussed. |
راعي المشروع | Partial support from Qatar University is acknowledged. Open Access funding provided by the Qatar National Library. |
اللغة | en |
الناشر | Elsevier |
الموضوع | Diclofenac Photoconversion Fluorescence Solvent effects Solvatochromic models |
النوع | Article |
رقم العدد | 11 |
رقم المجلد | 9 |
Open Access user License | http://creativecommons.org/licenses/by/4.0/ |
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