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المؤلفRamli, Iman
المؤلفCheriet, Thamere
المؤلفPosadino, Anna Maria
المؤلفGiordo, Roberta
المؤلفZayed, Hatem
المؤلفEid, Ali H.
المؤلفPintus, Gianfranco
تاريخ الإتاحة2024-01-29T09:46:38Z
تاريخ النشر2023-09-14
اسم المنشورFrontiers in Bioscience - Landmark
المعرّفhttp://dx.doi.org/10.31083/j.fbl2809198
الاقتباسRamli, I., Cheriet, T., Posadino, A. M., Giordo, R., Zayed, H., Eid, A. H., & Pintus, G. (2023). Potential therapeutic targets of resveratrol in the prevention and treatment of pulmonary fibrosis. Frontiers in Bioscience-Landmark, 28(9), 198.
الرقم المعياري الدولي للكتاب2768-6701
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85174623807&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/51319
الملخصPulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases, which are characterized by increased alveolar wall thickness, excessive scarring, and aberrant extracellular matrix restructuring that, ultimately, affect lung compliance and capacity. As a result of its broad range of biological activities, including antioxidant, anti-inflammatory, antiapoptotic, and many others, resveratrol has been shown to be an effective treatment for respiratory system diseases, including interstitial lung disease, infectious diseases, and lung cancer. This work reviews the known molecular therapeutic targets of resveratrol and its potential mechanisms of action in attenuating PF in respiratory diseases, including cancer, COVID-19, interstitial lung diseases (ILDs) of known etiologies, idiopathic interstitial pneumonia, and ILDs associated with systemic disorders, such as rheumatoid arthritis, systemic sclerosis, Schrödinger’s syndrome, systemic lupus erythematosus, and pulmonary hypertension. The current issues and controversies related to the possible use of resveratrol as a pharmaceutical drug or supplement are also discussed.
راعي المشروعThis work has been made possible thanks to grants from “Progetto Fondazione di Sardegna-Bando 2022–2023”, “FAR2020-Pintus”, and “DM 737/2021 resources 2021–2022, funded by the European Union - NextGenerationEU”.
اللغةen
الناشرIMR Press Limited
الموضوعinterstitial lung diseases
Nrf2
pulmonary fibrosis
resveratrol
SIRT1
TGF-ß1
العنوانPotential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis
النوعArticle
رقم العدد9
رقم المجلد28
ESSN2768-6698
dc.accessType Open Access


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