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المؤلفBurgon, Patrick G.
المؤلفWeldrick, Jonathan J.
المؤلفTalab, Omar Mohamed Sayed Ahmed
المؤلفNadeer, Muhammad
المؤلفNomikos, Michail
المؤلفMegeney, Lynn A.
تاريخ الإتاحة2024-01-29T10:26:10Z
تاريخ النشر2023-09-21
اسم المنشورCells
المعرّفhttp://dx.doi.org/10.3390/cells12182324
الاقتباسBurgon, P. G., Weldrick, J. J., Talab, O. M. S. A., Nadeer, M., Nomikos, M., & Megeney, L. A. (2023). Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes. Cells, 12(18), 2324.
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85172778592&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/51323
الملخصHeart disease remains a global leading cause of death and disability, necessitating a comprehensive understanding of the heart’s development, repair, and dysfunction. This review surveys recent discoveries that explore the developmental transition of proliferative fetal cardiomyocytes into hypertrophic postnatal cardiomyocytes, a process yet to be well-defined. This transition is key to the heart’s growth and has promising therapeutic potential, particularly for congenital or acquired heart damage, such as myocardial infarctions. Although significant progress has been made, much work is needed to unravel the complex interplay of signaling pathways that regulate cardiomyocyte proliferation and hypertrophy. This review provides a detailed perspective for future research directions aimed at the potential therapeutic harnessing of the perinatal heart transitions.
راعي المشروع- QU Internal Grant [QUST-2-CMED-2021-204]. - Qatar University Collaborative Grant [QUCG-CAS-23/24-214]. - QU Internal Grant [QUCG-CMED-22/23-514]. - Canadian Institute of Health Research Funding [#169089]. - Queen Elizabeth II Graduate Scholarship (QEII-GSST) - University of Ottawa Excellence Scholarship.
اللغةen
الناشرMultidisciplinary Digital Publishing Institute (MDPI)
الموضوعfetal to postnatal development
hypertrophy and proliferation
micro-RNA
signaling pathways (mTOR, Hippo, YAP/TAZ)
therapeutic potential
العنوانRegulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes
النوعArticle
رقم العدد18
رقم المجلد12
ESSN2073-4409
dc.accessType Open Access


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