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AuthorBurgon, Patrick G.
AuthorWeldrick, Jonathan J.
AuthorTalab, Omar Mohamed Sayed Ahmed
AuthorNadeer, Muhammad
AuthorNomikos, Michail
AuthorMegeney, Lynn A.
Available date2024-01-29T10:26:10Z
Publication Date2023-09-21
Publication NameCells
Identifierhttp://dx.doi.org/10.3390/cells12182324
CitationBurgon, P. G., Weldrick, J. J., Talab, O. M. S. A., Nadeer, M., Nomikos, M., & Megeney, L. A. (2023). Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes. Cells, 12(18), 2324.
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85172778592&origin=inward
URIhttp://hdl.handle.net/10576/51323
AbstractHeart disease remains a global leading cause of death and disability, necessitating a comprehensive understanding of the heart’s development, repair, and dysfunction. This review surveys recent discoveries that explore the developmental transition of proliferative fetal cardiomyocytes into hypertrophic postnatal cardiomyocytes, a process yet to be well-defined. This transition is key to the heart’s growth and has promising therapeutic potential, particularly for congenital or acquired heart damage, such as myocardial infarctions. Although significant progress has been made, much work is needed to unravel the complex interplay of signaling pathways that regulate cardiomyocyte proliferation and hypertrophy. This review provides a detailed perspective for future research directions aimed at the potential therapeutic harnessing of the perinatal heart transitions.
Sponsor- QU Internal Grant [QUST-2-CMED-2021-204]. - Qatar University Collaborative Grant [QUCG-CAS-23/24-214]. - QU Internal Grant [QUCG-CMED-22/23-514]. - Canadian Institute of Health Research Funding [#169089]. - Queen Elizabeth II Graduate Scholarship (QEII-GSST) - University of Ottawa Excellence Scholarship.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjectfetal to postnatal development
hypertrophy and proliferation
micro-RNA
signaling pathways (mTOR, Hippo, YAP/TAZ)
therapeutic potential
TitleRegulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes
TypeArticle
Issue Number18
Volume Number12
ESSN2073-4409
dc.accessType Open Access


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