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المؤلفElshafei, Mohamed Nabil
المؤلفEl-Bardissy, Ahmed
المؤلفKhalil, Ahmed
المؤلفDanjuma, Mohammed
المؤلفMubasher, Mahmood
المؤلفAbubeker, Ibrahim Y.
المؤلفMohamed, Mouhand F.H.
تاريخ الإتاحة2024-02-14T10:28:46Z
تاريخ النشر2021-06-29
اسم المنشورEuropean Journal of Clinical Investigation
المعرّفhttp://dx.doi.org/10.1111/eci.13645
الاقتباسElshafei, M. N., El‐Bardissy, A., Khalil, A., Danjuma, M., Mubasher, M., Abubeker, I. Y., & Mohamed, M. F. (2021). Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis. European journal of clinical investigation, 51(9), e13645.
الرقم المعياري الدولي للكتاب0014-2972
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85110554156&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/51841
الملخصBackground: Colchicine was recently repurposed for the management of coronavirus disease 2019 (COVID-19). This rapid review and meta-analysis aimed to assess colchicine's impact on mortality outcomes in COVID-19 patients. Materials and Methods: We systematically searched PubMed, EMBASE, Google Scholar since their inception till 25/03/2021 for observational or controlled studies that reported mortality as an outcome. The mortality odd ratios were generated with their corresponding 95% confidence intervals utilizing the random-effects model. Results: Nine studies comprising 5522 patients met our inclusion criteria. Our meta-analysis revealed significantly lower mortality in the colchicine group (OR 0.35, 95% CI 0.25-0.48, I2 0%) compared with controls. A subgroup analysis limited to hospitalized patients (OR 0.35, 95% CI 0.25-0.50, I2 0%) revealed similarly lower mortality in the colchicine group. Conclusions: This meta-analysis suggests a mortality benefit with colchicine when used in the treatment of COVID-19 patients. The majority of included studies were observational; thus, the findings of this review need to be further supported by the results of ongoing trials.
راعي المشروعOpen Access funding provided by the Qatar National Library.
اللغةen
الناشرWiley-Blackwell
الموضوعcolchicine
coronavirus disease 2019
COVID-19
mortality
SARS-CoV-2
العنوانColchicine use might be associated with lower mortality in COVID-19 patients: A meta-analysis
النوعArticle
رقم العدد9
رقم المجلد51
ESSN1365-2362
dc.accessType Open Access


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