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AuthorElshafei, Mohamed Nabil
AuthorEl-Bardissy, Ahmed
AuthorKhalil, Ahmed
AuthorDanjuma, Mohammed
AuthorMubasher, Mahmood
AuthorAbubeker, Ibrahim Y.
AuthorMohamed, Mouhand F.H.
Available date2024-02-14T10:28:46Z
Publication Date2021-06-29
Publication NameEuropean Journal of Clinical Investigation
Identifierhttp://dx.doi.org/10.1111/eci.13645
CitationElshafei, M. N., El‐Bardissy, A., Khalil, A., Danjuma, M., Mubasher, M., Abubeker, I. Y., & Mohamed, M. F. (2021). Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis. European journal of clinical investigation, 51(9), e13645.
ISSN0014-2972
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85110554156&origin=inward
URIhttp://hdl.handle.net/10576/51841
AbstractBackground: Colchicine was recently repurposed for the management of coronavirus disease 2019 (COVID-19). This rapid review and meta-analysis aimed to assess colchicine's impact on mortality outcomes in COVID-19 patients. Materials and Methods: We systematically searched PubMed, EMBASE, Google Scholar since their inception till 25/03/2021 for observational or controlled studies that reported mortality as an outcome. The mortality odd ratios were generated with their corresponding 95% confidence intervals utilizing the random-effects model. Results: Nine studies comprising 5522 patients met our inclusion criteria. Our meta-analysis revealed significantly lower mortality in the colchicine group (OR 0.35, 95% CI 0.25-0.48, I2 0%) compared with controls. A subgroup analysis limited to hospitalized patients (OR 0.35, 95% CI 0.25-0.50, I2 0%) revealed similarly lower mortality in the colchicine group. Conclusions: This meta-analysis suggests a mortality benefit with colchicine when used in the treatment of COVID-19 patients. The majority of included studies were observational; thus, the findings of this review need to be further supported by the results of ongoing trials.
SponsorOpen Access funding provided by the Qatar National Library.
Languageen
PublisherWiley-Blackwell
Subjectcolchicine
coronavirus disease 2019
COVID-19
mortality
SARS-CoV-2
TitleColchicine use might be associated with lower mortality in COVID-19 patients: A meta-analysis
TypeArticle
Issue Number9
Volume Number51
ESSN1365-2362
dc.accessType Open Access


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