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AuthorBenjamin, Ellis
AuthorHijji, Yousef M.
Available date2024-02-27T09:36:19Z
Publication Date2017-01-01
Publication NameJournal of Chemistry
Identifierhttp://dx.doi.org/10.1155/2017/6436185
CitationBenjamin, E., & Hijji, Y. M. (2017). A novel green synthesis of thalidomide and analogs. Journal of Chemistry, 2017.‏
ISSN20909063
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029367412&origin=inward
URIhttp://hdl.handle.net/10576/52295
AbstractThalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.
Languageen
PublisherHindawi Limited
SubjectNovel
TitleA Novel Green Synthesis of Thalidomide and Analogs
TypeArticle
Volume Number2017
dc.accessType Open Access


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