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المؤلفShaker, Mohamed A.
المؤلفDoré, Jules J.E.
المؤلفYounes, Husam M.
تاريخ الإتاحة2024-02-27T11:40:56Z
تاريخ النشر2010-03-01
اسم المنشورJournal of Biomaterials Science, Polymer Edition
المعرّفhttp://dx.doi.org/10.1163/156856209X429157
الاقتباسShaker, M. A., Doré, J. J., & Younes, H. M. (2010). Synthesis, characterization and cytocompatibility of a poly (diol-tricarballylate) visible light photo-cross-linked biodegradable elastomer. Journal of Biomaterials Science, Polymer Edition, 21(4), 507-528.
الرقم المعياري الدولي للكتاب0920-5063
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77949600549&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/52325
الملخصThe synthesis, characterization and in vitro cytocompatibility of a new family of photo-cross-linked amorphous poly(diol-tricarballylate) (PDT) biodegradable elastomeric polyesters are reported. The synthesis was based on the polycondensation reaction between tricarballylic acid and alkylene diols, followed by acrylation. The prepared and acrylated poly(diol-tricarballylate) (APDT) was characterized by means of FT-IR, 1H-NMR, GPC and DSC. Liquid-to-solid photo-curing was carried out by exposing the APDT to visible light in the presence of camphorquinone as a photoinitiator. The thermal properties, mechanical characteristics, sol content, long-term in vitro degradation and cytocompatibility of the prepared PDT elastomers were also reported. The mechanical and degradation properties of this new photocurable elastomer can be precisely controlled by varying the density of acrylate moieties in the matrix of the polymer, and through changes in the pre-polymer chain length. The use of visible light cross-linking, possibility of solventless drug loading, controllable mechanical properties and cytocompatibility of these new elastomers make them excellent candidates for use in controlled implantable drug-delivery systems of protein drugs and other biomedical applications. © Koninklijke Brill NV, Leiden, 2010.
راعي المشروعThis work has been financially supported by a grant from the Natural Sciences and Engineering Research Council of Canada (NSERC).
اللغةen
الناشرTaylor & Francis
الموضوعCytocompatibility
Degradation
Elastomer
Photo-polymerization
Poly(diol-tricarballylate)
العنوانSynthesis, characterization and cytocompatibility of a poly(diol- tricarballylate) visible light photo-cross-linked biodegradable elastomer
النوعArticle
الصفحات507-528
رقم العدد4
رقم المجلد21
ESSN1568-5624
dc.accessType Full Text


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