Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway
Author | Sampath, Chethan |
Author | Rashid, Muhammed |
Author | Sang, Shengmin |
Author | Ahmedna, Mohamed |
Available date | 2017-02-13T09:29:32Z |
Publication Date | 2017-01-16 |
Publication Name | Food Chemistry |
Identifier | http://dx.doi.org/10.1016/j.foodchem.2017.01.056 |
Citation | Sampath, Chethan. Rashid, Muhammed. Sang, Shengmin. Ahmedna, Mohamed. "Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway", Food Chemistry, Vol. 226, pp. 79-88 |
ISSN | 0308-8146 |
Abstract | Prolonged hyperglycemia activates the formation of advanced glycation end-products (AGEs). Major dicarbonyl compounds such as methylglyoxal or glyoxal are found to be the main precursors of AGEs and N(e)-(carboxymethyl)lysine (CML) found to be predominantly higher in the diabetic population. We hypothesized that phloretin from apple and [6]-gingerol from ginger inhibit formation of AGEs and suppress the receptor for advanced glycation end products (RAGE) via nuclear factor erythroid-2- related-factor-2 (Nrf2)-dependent pathway. Phloretin and [6]-gingerol were supplemented at two different doses to C57BL/6 mice on high fat diet or standard diet for a period of 17 weeks. Phloretin or [6]- gingerol supplementation significantly reduced plasma glucose, alanine aminotransferase, aspartate aminotransferase, AGEs and insulin levels. Phloretin and [6]-gingerol also decreased the levels of AGEs and CML levels, via Nrf2 pathway, enhancing GSH/GSSG ratio, heme oxygenase-1 and glyoxalase 1 in liver tissue. These results suggest that phloretin and [6]-gingerol are potential dietary compounds that can alleviate diabetes-induced complications. |
Sponsor | Qatar National research Fund |
Language | en |
Publisher | Elsevier |
Subject | Advance glycation end-products Phloretin [6]-Gingerol Nrf2 RAGE GSH |
Type | Article |
Pagination | 79-88 |
Volume Number | 226 |
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Human Nutrition [371 items ]