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المؤلفKarim, Mustafa Abdul
المؤلفAl-Baz, Nadeen
المؤلفHaddad, Peter M.
المؤلفReagu, Shuja M.
المؤلفAlabdulla, Majid
تاريخ الإتاحة2024-03-04T03:41:15Z
تاريخ النشر2021
اسم المنشورMedicine (United States)
المصدرScopus
الرقم المعياري الدولي للكتاب257974
معرّف المصادر الموحدhttp://dx.doi.org/10.1097/MD.0000000000028003
معرّف المصادر الموحدhttp://hdl.handle.net/10576/52585
الملخصRationale: Irritable bowel syndrome (IBS) is a chronic and debilitating functional disorder of the gastrointestinal tract manifested by abdominal pain and bowel habit dysregulation. The pathophysiology is complex and management targets symptom resolution. Therapeutic interventions range from dietary modification, psychological interventions, exercise, to the use of antispasmodics, antibiotics, and antidepressants. Anecdotal reports have suggested that buspirone may be beneficial in the treatment of functional dyspepsia and IBS and its physiological effect of reducing gastric tone provides a rational for its benefit. Patient concerns: A 28-year-old man with unremarkable past medical and psychiatric history presented with worsening abdominal pain, bloating, and bowel movement dysregulation of over 6-year duration. Diagnoses: Physical examination revealed mild distension and discomfort on deep palpation. Thorough blood investigations, stool analysis and culture, and imaging were unremarkable except for the detection of mucus with stool. The patient was diagnosed with irritable bowel syndrome with mixed habits. Interventions: Dietary adjustment and a range of medications (mebeverine, simethicone, loperamide, rifaximin, sertraline and amitriptyline) yielded unsatisfactory response of were not tolerated. Buspirone was eventually introduced. Outcomes: Buspirone was associated with a significant and sustained improvement in IBS symptoms and quality of life. Lessons: This case suggests that buspirone was effective in treating refractory IBS. Further research is needed to assess the role of buspirone in IBS management.
اللغةen
الناشرLippincott Williams and Wilkins
الموضوعAbdominal pain
Buspirone
Irritable bowel syndrome
العنوانBuspirone in the management of refractory irritable bowel syndrome A case report
النوعArticle
الصفحاتE28003
رقم العدد51
رقم المجلد100
dc.accessType Open Access


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